PMID: 9557753Apr 29, 1998Paper

Single amino acid insertion in loop 4 confers amphotropic murine leukemia virus receptor function upon murine Pit1

Journal of Virology
M D LundorfL Pedersen

Abstract

Pit1 is the human receptor for gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B), while the related human protein Pit2 is a receptor for amphotropic murine leukemia virus (A-MuLV). The A-MuLV-related isolate 10A1 can utilize both Pit1 and Pit2 as receptors. A stretch of amino acids named region A was identified in Pit1 (residues 550 to 558 in loop 4) as critical for GALV and FeLV-B receptor function. We have here investigated the role of region A in A-MuLV and 10A1 entry. Insertion of a single amino acid in region A of mouse Pit1 resulted in a functional A-MuLV receptor, showing that region A plays a role in A-MuLV infection. Moreover, the downregulation of 10A1 receptor function by changes in region A of human Pit1 indicates that this region is also involved in 10A1 entry. Therefore, region A seems to play a role in infection by all viruses utilizing Pit1 and/or Pit2 as receptors.

References

Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·W K Versaw, R L Metzenberg
Dec 1, 1994·Journal of Virology·D G Miller, A D Miller
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·M P KavanaughA D Miller
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Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·M van ZeijlB O'Hara
Jul 1, 1993·Virology·J R McLachlinM A Eglitis

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Citations

Aug 17, 2004·Journal of Virology·Pernille Bøttger, Lene Pedersen
Jan 29, 2003·Journal of Virology·Anna L BarnettJames M Cunningham

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