Single and composite influence of growth-related candidate gene polymorphisms on additive genetic variation of birth weight in Charolais beef cattle

Tropical Animal Health and Production
Gaspar Manuel Parra-BracamonteLuis Alberto Meza-Garcia

Abstract

The objective of the present experiment work was to evaluate the effect of the inclusion of genomic information on the additive genetic variance of birth weight (BW) of Charolais cattle in Mexico. Variance components and heritability were estimated using four linear models. The first model was the base model (BM) from which single and composite effects of selected single-nucleotide polymorphism (SNP) markers were evaluated (BM1, BM2, and a composite BM3). Genetic markers were included in a regression model and analyzed by stepwise regression against adjusted BW from a panel of growth-related traits candidate gene markers. After two regression rounds, two SNPs (R (2) > 0.02) were chosen to include into the animal models as fixed effects. Growth hormone receptor gene GHR 4.2 and GHR 6.1 SNPs were selected from a panel of 39 SNPs. GHR 4.2 had a negligible effect on BW, whilst GHR6.1, interestingly, explained ∼9 % of genetic variance (p = 0.0877) with an αG>A = 0.509. The inclusion of markers in M2 and M3 reduced 19 and 15 % of the additive genetic variance, respectively. Both adjusted significantly better the linear model (LRT = p < 0.01). Results obtained suggest that the previous selection of markers in a candidate gene approach...Continue Reading

References

Aug 1, 1971·Journal of Animal Science·R A BellowsO F Pahnish
Nov 14, 2007·International Journal of Biological Sciences·Mengjin Zhu, Shuhong Zhao
Dec 14, 2007·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M E Goddard, B J Hayes
Apr 28, 2011·Genetics and Molecular Research : GMR·L GaoX Zhong
Jan 10, 2012·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·S M WatersM P Mullen

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