Single and multi-layered nanofibers for rapid and controlled drug delivery

Chemical & Pharmaceutical Bulletin
Anahita Fathi-Azarbayjani, Sui Yung Chan

Abstract

This paper introduces a new delivery system for rapid and controlled drug release. Mixture of hydrophilic, (poly vinyl alcohol, PVA, and randomly methylated beta-cyclodextrin, RM beta-CD), and hydrophobic (poly D,L-lactide, PLA, and poly D,L-lactide-co-glycoside, PLGA) polymers were electrospun to make a multi-layered/multicomponent nanofiber mat. The release characteristics of the drug were modified using the layer by layer approach to help compensate the limitation of the individual materials. Incorporation of RM beta-CD to the PVA solution was able to significantly decrease the degradation rate of the resulting fiber mat from a few weeks to a few seconds. Hydrophilic polymer mat (PVA-RM beta-CD) can dissolve in the release media instantly and provide rapid release of the drug. This characteristic makes such carriers suitable as sublingual delivery systems in the treatment of acute disorders. Polyesters, PLA and PLGA, can control drug release via hydrolysis of the polymer and provide sustained and controlled release of the drug. Blends of these hydrophilic and hydrophobic polymers can effectively prolong drug release and decrease physiological toxicity resulting from fast release of drugs. These carriers may be suitable for t...Continue Reading

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Citations

Jul 28, 2010·AAPS PharmSciTech·Anahita Fathi-AzarbayjaniSui Yung Chan
Sep 16, 2011·Journal of Pharmaceutical Sciences·Zsombor K NagyGyörgy Marosi
Aug 27, 2015·International Journal of Pharmaceutics·István SebeRomána Zelkó
Jun 1, 2011·Journal of Biomedical Materials Research. Part a·Wei SongDavid C Markel
Dec 19, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Weiping P RenDavid C Markel
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Roberta F BonanJuliano E Oliveira
Feb 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro CostoyaCarmen Alvarez-Lorenzo
Nov 16, 2013·Archives of Pharmacal Research·Young Ju SonHyuk Sang Yoo
Jan 26, 2021·International Journal of Pharmaceutics·Tahereh MirmajidiAli Mohammad Sharifi
May 10, 2021·International Journal of Biological Macromolecules·Parvaneh Ghaderi Shikhi-Abadi, Mohammad Irani

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