PMID: 7362955Feb 1, 1980

Single and multiple dose cotrimoxazole and metronidazole in colorectal surgery

The British Journal of Surgery
A F HigginsM L Hole


Cotrimoxazole and metronidazole were given prophylactically to patients undergoing colorectal surgery as a single preoperative dose or in multiple doses for 5 days. A total of 60 operations randomly divided into two groups showed that the rate of wound infection was low in both groups and there was no statistical difference between them. There were no cases of anastomotic dehiscence in those patients where the anastomosis was carried out from within the abdomen, but 7 out of 9 patients with transphincteric colo-anastomoses developed a suture line dehiscence. A greater degree of post-catheterization urinary tract infection was seen in the single dose group (which lacks statistical significance). There were no toxic effects.


Jul 2, 1977·Lancet·R S FeathersP Noone
Aug 12, 1978·British Medical Journal·C MorranC S McArdle
Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·P NooneJ M Bradley
Aug 1, 1976·The Australian and New Zealand Journal of Surgery·B McCluskey
Sep 1, 1974·The British Journal of Surgery·E J StokesC G Clark
Nov 25, 1972·British Medical Journal·L P Garrod
Feb 1, 1970·The British Journal of Surgery·J C GoligherF T De Dombal


Jan 1, 1986·European Journal of Clinical Pharmacology·A Rubenson, A Rosetzsky
May 1, 1982·World Journal of Surgery·D W Burdon
May 1, 1982·World Journal of Surgery·M R Keighley
Dec 1, 1984·European Journal of Clinical Microbiology·F MoesgaardT Justesen
Mar 1, 1984·Diseases of the Colon and Rectum·F MoesgaardT Justesen
Nov 1, 1989·Irish Journal of Medical Science·P CurleyD Bouchier-Hayes
Feb 1, 1982·Journal of Toxicology and Environmental Health·H S Buttar
Apr 17, 2003·Surgical Infections·Daniel P RaymondRobert G Sawyer
Jun 12, 1998·The Australian and New Zealand Journal of Surgery·M McDonaldA Forbes
Sep 13, 1980·British Medical Journal·N A Matheson, D Valerio
Jun 11, 1983·British Medical Journal·M R Keighley
Oct 20, 1990·BMJ : British Medical Journal·B D Hancock
Nov 1, 1991·Infection·N Rangabashyam, A Rathnasami
Nov 1, 1986·American Journal of Surgery·J T DiPiroJ A Mansberger
Feb 1, 1985·British Journal of Urology·W R Allan, A Kumar
Dec 1, 1996·American Journal of Surgery·D H Wittmann, M Schein
Jan 1, 1984·Scandinavian Journal of Infectious Diseases. Supplementum
Nov 1, 1989·The Veterinary Clinics of North America. Small Animal Practice·R J Murtaugh, G D Mason
May 2, 2002·ANZ Journal of Surgery·Yunus A GulKevin Moissinac
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
Aug 1, 1988·The British Journal of Surgery·W Y LauK K Ho
Feb 1, 1983·The British Journal of Surgery·G A Khoury, B P Waxman
Sep 1, 1982·World Journal of Surgery·J Alexander-Williams, M R Keighley
Jan 1, 1982·Infection·M WenzelB Neuhaus

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