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Single and multiple dose pharmacokinetics of dolutegravir in the genital tract of HIV-negative women

Antiviral Therapy

Jul 31, 2013

Jessica L AdamsAngela D M Kashuba

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Abstract

Antiretrovirals that achieve adequate concentrations in anatomical sites of transmission are of interest for HIV prevention. A Phase I open-label pharmacokinetic (PK) study was performed to describe first dose (PK1) and steady-state (PK2) PKs of the integrase inhibitor dolutegravir (DTG...read more

Mentioned in this Paper

Integrase Inhibitors
Plasma
Pharmacokinetic Aspects
Body Regions
Genital System
Anti-HIV Agents
Drug Kinetics
Dolutegravir
Vaginitis
Heterocyclic Compounds, 3-Ring
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  • Single and multiple dose pharmacokinetics of dolutegravir in the genital tract of HIV-negative women

    Antiviral Therapy

    Jul 31, 2013

    Jessica L AdamsAngela D M Kashuba

    PMID: 23899439

    DOI: 10.3851/imp2665

    Abstract

    Antiretrovirals that achieve adequate concentrations in anatomical sites of transmission are of interest for HIV prevention. A Phase I open-label pharmacokinetic (PK) study was performed to describe first dose (PK1) and steady-state (PK2) PKs of the integrase inhibitor dolutegravir (DTG...read more

    Mentioned in this Paper

    Integrase Inhibitors
    Plasma
    Pharmacokinetic Aspects
    Body Regions
    Genital System

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