PMID: 3266152Jan 1, 1988Paper

Single and multiple dose pharmacokinetics of tenoxicam in the elderly

European Journal of Clinical Pharmacology
O G NilsenE Thue

Abstract

Fourteen elderly subjects (10 women, 4 men) with a mean age of 81 (SD 6.7) years and in need of anti-inflammatory drug treatment were given a single dose of 20 mg tenoxicam. After a drug-free interval of 5 weeks, multiple dose treatment with 20 mg tenoxicam once daily for 56 days was initiated. The single and multiple dose kinetics of tenoxicam were investigated after HPLC determination of tenoxicam in the plasma. The elimination half-life of tenoxicam ranged from 44 to 132 h (mean 71.9 h) with no significant difference between the single and multiple dosage regimens. Tenoxicam reached maximum plasma concentrations after 1.4 and 1.1 h, with values of 3.6 and 15.5 micrograms.ml-1, for the single and multiple dosage regimen respectively. The corresponding trough values (24-h values) were 1.8 and 11.7 micrograms.ml-1. A mean accumulation ratio of 5.1 was calculated. The mean increase in the area under the plasma concentration time curves at steady-state was 21% more than predicted from the initial single dose. This deviation from linearity was considered to be of minor clinical significance. The kinetics of tenoxicam in elderly were similar to that published for young healthy volunteers.

References

Jan 10, 1986·Journal of Chromatography·P HeizmannK Zinapold
Jan 1, 1986·European Journal of Clinical Pharmacology·F F HorberF J Frey
Nov 1, 1985·British Journal of Rheumatology·H A BirdV Wright

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Citations

Nov 1, 1992·The Journal of Pharmacy and Pharmacology·L G Lopez-BustamanteD Fos
Jul 10, 2010·Thrombosis Research·Fernanda A OrsiKaren E Weck
Sep 8, 2004·Journal of Pharmaceutical and Biomedical Analysis·J A AcuñaP Sánchez-Batanero
Jan 1, 1989·Scandinavian Journal of Rheumatology. Supplement·M Schmitt, T W Guentert
Dec 5, 2006·Journal of Pharmaceutical and Biomedical Analysis·Iulia SoraAndrei Medvedovici
Mar 15, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tamer AkcaSuha Aydin

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