PMID: 639828Mar 17, 1978Paper

Single and multiple dose pharmacokinetics of pindolol

European Journal of Clinical Pharmacology
R Gugler, G Bodem

Abstract

The pharmacokinetics of pindolol were studied in six healthy individuals following a single 10 mg dose (SD) and multiple (5 mg tid over 6 days) dose (MD). The plasma elimination half-life was identical after SD (4.7 +/- 0,8h) and MD (4.1 +/- 1.1h). Steady state plasma concentrations were reached after 36 h and remained stable thereafter. The variation in steady state concentrations was small in each individual and also between individuals. The steady state concentration of pindolol can be predicted from the pharmacokinetic data obtained after a single dose. The results of the present study suggest that the disposition of pindolol is linear over the concentration range studied.

References

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Citations

Jan 1, 1982·European Journal of Clinical Pharmacology·E E OhnhausG Maurer
Jan 1, 1981·European Journal of Clinical Pharmacology·W H AelligW Pacha
Jan 1, 1982·European Journal of Clinical Pharmacology·E E OhnhausJ Meier
Jan 1, 1981·European Journal of Clinical Pharmacology·L BalantJ Fabre
Jul 1, 1983·Human Toxicology·A H Stead, A C Moffat
Aug 1, 1979·European Journal of Clinical Pharmacology·U AbshagenH Stork
Dec 22, 1996·Proceedings. Biological Sciences·M RaymondA P Møller
Feb 24, 2001·Journal of Clinical Psychopharmacology·V PérezUNKNOWN Grup de Recerca en Trastorns Afectius
Jun 12, 1979·European Journal of Clinical Pharmacology·L A SalakoR A Adio
Oct 1, 1980·British Journal of Clinical Pharmacology·R GuglerG Bodem
Jan 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G MaurerJ Meier

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