Single and multiple sevoflurane exposures during pregnancy and offspring behavior in mice

Paediatric Anaesthesia
Soomin LeeYoungkwon Ko

Abstract

The second trimester is a period of neurogenesis and neuronal migration, which can be affected by exposure to anesthetics. Studies also suggest that multiple exposures may have a greater impact on neurodevelopment. We investigated whether in utero single or multiple exposures to anesthetics caused long-term behavior changes. Pregnant mice were randomly divided into four groups on gestational day 14 (GD 14). Mice in the Control × 1 group were exposed to 100% oxygen for 150 min. Mice in the Sevo × 1 group were also exposed to 100% oxygen for 150 min, except that 2.5% sevoflurane was added during the first 120 min. Mice in the Control × 3 and Sevo × 3 group were identically treated as Control × 1 and Sevo × 1 group for three consecutive days, respectively (GD 14-16). Behavioral tests were performed only with the male offspring at the age of 2-4 months. Synaptic plasticity was also compared by inducing long-term potentiation in acute hippocampal slices. Single or multiple sevoflurane exposures in pregnant mice during the second trimester did not cause long-lasting behavioral consequences or changes in long-term synaptic plasticity of their offspring. Our study suggests that neither single nor multiple exposures of mice to sevoflura...Continue Reading

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References

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Citations

Dec 12, 2017·Korean journal of anesthesiology·Hyungseok Seo, Jae-Woo Yi
Dec 12, 2017·Korean journal of anesthesiology·Woosuk ChungYong Sup Shin
Feb 13, 2018·European Journal of Anaesthesiology·Sebastian HeiderichWerner Klingler
Dec 2, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yong ZuoZhenhua Shi
Feb 19, 2021·Frontiers in Pharmacology·Xingyue LiPing Zhao

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