Single and staged laser interstitial thermal therapy ablation for cortical tubers causing refractory epilepsy in pediatric patients

Neurosurgical Focus
Zulma Tovar-SpinozaStephanie Zyck

Abstract

OBJECTIVE Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive treatment for the surgical treatment of epilepsy. In this paper, the authors report on clinical outcomes for a series of pediatric patients with tuberous sclerosis complex (TSC) and medication-refractory epileptogenic cortical tubers. METHODS A retrospective chart review was performed at SUNY Upstate Golisano Children's Hospital in Syracuse, New York. The authors included all cases involving pediatric patients (< 18 years) who underwent MRgLITT for ablation of epileptogenic cortical tubers between February 2013 and November 2015. RESULTS Seven patients with cortical tubers were treated (4 female and 3 male). The patients' average age was 6.6 years (range 2-17 years). Two patients had a single procedure, and 5 patients had staged procedures. The mean time between procedures in the staged cases was 6 months. All of the patients had a meaningful reduction in seizure frequency as reported by Engel and ILAE seizure outcome classifications, and most (71.4%) of the patients experienced a reduction in AED burden. Three of the 4 patients who presented with neuropsychiatric symptoms had some improvement in these domains after l...Continue Reading

References

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Citations

Feb 27, 2019·Current Neurology and Neuroscience Reports·Sean T HwangSimona V Proteasa
Apr 11, 2019·Journal of Neurosurgery. Pediatrics·Jarod Roland, Matthew Smyth
Jul 17, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Madison RemickTaylor J Abel
Sep 4, 2018·Neurosurgical Focus·Erin N Kiehna, Robert J Bollo
Sep 21, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Andrea FranziniFrancesco Prada
Apr 1, 2020·Epilepsia·Christian DorferArthur Cukiert
Jun 19, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Michael A StellonChima O Oluigbo
Jun 15, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jeffrey M TreiberJonathan Roth
Sep 27, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Paolo FrassanitoGianpiero Tamburrini
Jul 4, 2021·Neurologic Clinics·Elaine S Seto, Rohini Coorg
Aug 6, 2021·Therapeutic Advances in Neurological Disorders·Susanne Schubert-Bast, Adam Strzelczyk

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Methods Mentioned

BETA
surgical resection

Software Mentioned

BrainLab iPlan
MRgLITT

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