Single and temporally displaced second nerve lesions in an animal model and their clinical significance

HNO
N-C GellrichJ Schipper

Abstract

Surgical optic decompression after trauma has been discussed controversially. The surgical trauma is supposed to produce an additional nerve lesion with the danger of complete loss of vision. Alternatively, conservative high dose cortisone therapy has been recommended. The functional and morphological consequences of a lesion after calibrated optic compression in one or two sessions were examined in an animal model using 29 Wistar rats. Depending on the duration and intensity of the lesion, we observed a linear decline in the number of neurons in the RGC (retinal ganglion cell) layer as well as an increasing reactivity to GFAP (glial fibrillary acidic protein) as an indication of central gliosis of astrocytes; however, this was independent on whether optic compression was performed in one or two sessions. To reduce secondary damage to the visual nerve and the central visual system that might increase with a persisting lesion, the indication for surgical relief of an eye affected by afference should be considered liberally, especially in view of the low morbidity of rhinosurgical intervention.

References

Mar 1, 1978·Journal of Neurosurgery·J E Maniscalco, M B Habal
Jun 1, 1976·Archives of Ophthalmology·J S KennerdellE N Myers
Aug 1, 1992·The British Journal of Radiology·A BerlisM Schumacher
Dec 15, 1990·American Journal of Ophthalmology·T C SpoorM J Wilkinson
Apr 15, 1990·American Journal of Ophthalmology·M J Wolin, P J Lavin
May 1, 1988·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·J Raveh, T Vuillemin
Nov 1, 1988·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·J Raveh, T Vuillemin
Jan 1, 1987·Archives of Otolaryngology--head & Neck Surgery·A F LipkinR H Miller
Dec 1, 1968·Archives of Ophthalmology·J A Stanley, G R Baise
Jun 1, 1984·Neurosurgery·L B KlineS N Swaid
Nov 1, 1981·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W R PanjeR L Anderson
Feb 1, 1981·The Laryngoscope·R A Sofferman
Dec 1, 1994·International Journal of Oral and Maxillofacial Surgery·N C GellrichA Bremerich
Feb 24, 2001·The Laryngoscope·B LübbenU Grenzebach
Jan 30, 2002·The British Journal of Ophthalmology·Nils-Claudius GellrichUlf Theodor Eysel
Jan 7, 2003·The Laryngoscope·A ThakarD A Tandon

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