PMID: 4901344Nov 22, 1969Paper

Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis

British Medical Journal
D T Hughes

Abstract

Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial, carried out as a single-blind procedure, showed that the combination was more effective as judged by clinical response and reduction in sputum volume and purulence, with eradication of pathogenic organisms. No appreciable side-effects were encountered with either treatment, and it is suggested that the trimethoprim-sulphamethoxazole combination may be a safe and useful drug in the treatment of chronic bronchitis.

References

Jan 28, 1967·British Medical Journal·P J Watt, O A Okubadejo
Jul 20, 1967·The New England Journal of Medicine·J R Tillotson, A M Lerner
Mar 1, 1969·British Medical Journal·D S ReevesW Brumfitt
Mar 1, 1969·British Medical Journal·R N Grüneberg, R Kolbe
Mar 1, 1968·Journal of Clinical Pathology·J H DarrellP M Waterworth
Nov 1, 1962·Journal of Medicinal and Pharmaceutical Chemistry·B ROTHS R BUSHBY

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Citations

May 1, 1972·The Journal of Clinical Pharmacology and New Drugs·Y LangloisL Tétreault
Mar 13, 1975·The New England Journal of Medicine·I Tager, F E Speizer
Dec 1, 1978·The Journal of Applied Bacteriology·L B QuesnelP Buddhavudhikrai
Jun 1, 1973·Australian and New Zealand Journal of Medicine·J KouttsM Cooper
Mar 1, 1979·Antimicrobial Agents and Chemotherapy·W E GroseT L Loo
Aug 1, 1972·Archives of Disease in Childhood·E M Poskitt, J M Parkin
Mar 11, 1972·British Medical Journal·I Chanarin, J M England
Aug 8, 1970·British Medical Journal·Z FaridS E Hathout
Jul 1, 1971·Journal of Clinical Pathology·D S Reeves
Jun 1, 1972·Journal of Clinical Pathology·B Chattopadhyay
Jan 1, 1973·Scandinavian Journal of Infectious Diseases·J A Raeburn, J D Devine
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·H V SardesaiA B Diwate
Jan 1, 1980·The American Journal of the Medical Sciences·W E Grose, G P Bodey
May 28, 2019·The Cochrane Database of Systematic Reviews·Christopher Jd ThreapletonEmma H Baker
Oct 30, 2018·The Cochrane Database of Systematic Reviews·Daniela J VollenweiderMilo A Puhan
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Daniela J VollenweiderMilo A Puhan
Apr 1, 1976·Thorax·B J Hartnett, G E Marlin
Jun 30, 1973·The Medical Journal of Australia·M W Burns, L Devitt
Aug 17, 2021·Frontiers in Microbiology·Hongmei ShiJiao-Yu Deng

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