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Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease

bioRxiv

Jan 6, 2020

M. Ryan CorcesThomas J Montine

Abstract

Genome-wide association studies (GWAS) have identified thousands of variants associated with disease phenotypes. However, the majority of these variants do not alter coding sequences, making it difficult to assign their function. To this end, we present a multi-omic epigenetic atlas of ...read more

Mentioned in this Paper

Three-dimensional
Locus
Tau Proteins
Landscapes
Gene Mutant
STAB1 protein, human
Neurons
Cohort
BIN1 protein
Oligodendroglia
123
Paper Details
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Single-cell epigenomic identification of inherited risk loci in Alzheimer's and Parkinson's disease

bioRxiv

Jan 6, 2020

M. Ryan CorcesThomas J Montine

DOI: 10.1101/2020.01.06.896159

Abstract

Genome-wide association studies (GWAS) have identified thousands of variants associated with disease phenotypes. However, the majority of these variants do not alter coding sequences, making it difficult to assign their function. To this end, we present a multi-omic epigenetic atlas of ...read more

Mentioned in this Paper

Three-dimensional
Locus
Tau Proteins
Landscapes
Gene Mutant
STAB1 protein, human
Neurons
Cohort
BIN1 protein
Oligodendroglia
123

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Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

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