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Single-cell profiles of retinal neurons differing in resilience to injury reveal neuroprotective genes

bioRxiv

Jul 23, 2019

Nicholas M. TranJoshua R. Sanes

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Abstract

Neuronal types in the central nervous system differ dramatically in their resilience to injury or insults. Here we studied the selective resilience of mouse retinal ganglion cells (RGCs) following optic nerve crush (ONC), which severs their axons and leads to death of ~80% of RGCs withi...read more

Mentioned in this Paper

Axon
Cessation of Life
Gene Expression
Genes
Laboratory mice
Nerve Degeneration
Neurons
Optic Nerve
Retina
Retinal Ganglion Cells
20
37
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Single-cell profiles of retinal neurons differing in resilience to injury reveal neuroprotective genes

bioRxiv

Jul 23, 2019

Nicholas M. TranJoshua R. Sanes

DOI: 10.1101/711762

Abstract

Neuronal types in the central nervous system differ dramatically in their resilience to injury or insults. Here we studied the selective resilience of mouse retinal ganglion cells (RGCs) following optic nerve crush (ONC), which severs their axons and leads to death of ~80% of RGCs withi...read more

Mentioned in this Paper

Axon
Cessation of Life
Gene Expression
Genes
Laboratory mice
20
37

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