PMID: 11325438Apr 28, 2001Paper

Single-cell recording from the brain of freely moving monkeys

Journal of Neuroscience Methods
N LudvigJ G Kral

Abstract

Single-cell recording from the brain of non-human primates has traditionally been performed in monkeys seated in a primate chair. However, this arrangement makes long-term recordings difficult, causes stress that may confound the data, and prevents the manifestation of natural behaviors. Extending our previous neurophysiological studies in non-human primates (Ludvig et al. Brain Res. Protocols 2000;5:75-85), we have developed a method for recording the electrical activity of single hippocampal neurons in freely moving squirrel monkeys (Saimiri sciureus). The recording sessions lasted for up to 6 h, during which the monkeys moved freely around on the walls and the floor of a large test chamber and collected food pellets. Stable action potential waveforms were readily kept throughout the sessions. The following factors proved to be critical in this study: (a) selecting squirrel monkeys for the experiments, (b) using a driveable bundle of microwires for the recordings, (c) using a special recording cable, (d) implanting the microwires into the brain without causing neurological deficits, and (e) running the recording sessions in a special test chamber. The described method allows long-term extracellular recordings from the brain o...Continue Reading

References

Jan 1, 1968·Electroencephalography and Clinical Neurophysiology·E V Evarts
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·L R Squire, S M Zola

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Citations

Jul 17, 2003·Journal of Neuroscience Methods·Fraser A W WilsonByoung Hoon Kim
Mar 20, 2003·Behavioural Brain Research·Nandor LudvigBaiju C Gohil
Mar 2, 2016·Journal of Neuroscience Methods·Allen YinMiguel A L Nicolelis
Jul 16, 2008·Journal of Neuroscience Methods·Helen Sherk, Elizabeth J Wilkinson
Mar 15, 2006·Methods : a Companion to Methods in Enzymology·Ning Lei SunFraser A W Wilson
Jun 6, 2009·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Cynthia A ChestekKrishna V Shenoy
Jun 24, 2008·Journal of Neuroscience Methods·Steven J Eliades, Xiaoqin Wang

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