Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy

International Journal of Neural Systems
Frédéric L W V J SchaperRob P W Rouhl

Abstract

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a promising treatment for patients with refractory epilepsy. However, therapy response varies and precise positioning of the DBS lead is potentially essential for maximizing therapeutic efficacy. We investigate if single-cell recordings acquired by microelectrode recordings can aid targeting of the ANT during surgery and hypothesize that the neuronal firing properties of the target region relate to clinical outcome. We prospectively included 10 refractory epilepsy patients and performed microelectrode recordings under general anesthesia to identify the change in neuronal signals when approaching and transecting the ANT. The neuronal firing properties of the target region, anatomical locations of microelectrode recordings and active contact positions of the DBS lead along the recorded trajectory were compared between responders and nonresponders to DBS. We obtained 19 sets of recordings from 10 patients (five responders and five nonresponders). Amongst the 403 neurons detected, 365 (90.6%) were classified as bursty. Entry into the ANT was characterized by an increase in firing rate while exit of the ANT was characterized by a decrease in firing rate. C...Continue Reading

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Citations

Apr 15, 2020·International Journal of Neural Systems·Rodrigo F O PenaAlexandra Olimpio Siqueira Cunha
Apr 21, 2020·International Journal of Neural Systems·Matthew LemingJohn Suckling
May 30, 2020·International Journal of Neural Systems·Francisco J Martinez-MurciaJuan Luis Luque
Dec 29, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Tim A M Bouwens van der VlisAlbert F G Leentjens
Feb 2, 2021·International Journal of Neural Systems·Delu MaFangzhou Xu

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