Single-cell RNA analysis on ACE2 expression provides insights into SARS-CoV-2 potential entry into the bloodstream and heart injury

Journal of Cellular Physiology
Jieyu GuoDan Meng

Abstract

Coronavirus disease-2019 (COVID-19) is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands of deaths worldwide. Recent studies have found that the pathogen of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shares the same cell receptor angiotensin converting enzyme II (ACE2) as SARS-CoV. The pathological investigation of COVID-19 deaths showed that the lungs had characteristics of pulmonary fibrosis. However, how SARS-CoV-2 spreads from the lungs to other organs has not yet been determined. Here, we performed an unbiased evaluation of cell-type-specific expression of ACE2 in healthy and fibrotic lungs, as well as in normal and failed adult human hearts, using published single-cell RNA-seq data. We found that ACE2 expression in fibrotic lungs mainly locates in arterial vascular cells, which might provide a route for bloodstream spreading of SARS-CoV-2. Failed human hearts have a higher percentage of ACE2-expressing cardiomyocytes, and SARS-CoV-2 might attack cardiomyocytes through the bloodstream in patients with heart failure. Moreover, ACE2 was highly expressed in cells infected by respiratory syncytial virus or Middle East respiratory syndrome coronavirus and in...Continue Reading

References

Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
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Citations

Aug 28, 2020·Open Biology·Vanessa WaznyChristine Cheung
Aug 12, 2020·Cellular and Molecular Life Sciences : CMLS·Jie WuXiuhong Yang
Nov 25, 2020·ESC Heart Failure·Sarah J CharmanDjordje G Jakovljevic
Dec 3, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Shatha K AlyammahiHany A Omar
Jan 15, 2021·Clinical Microbiology Reviews·Aleksandra SynowiecKrzysztof Pyrc
Mar 10, 2021·Journal of Investigative Medicine High Impact Case Reports·Abu Baker SheikhRahul Shekhar
Mar 7, 2021·International Journal of Molecular Sciences·Elvira ForteNadia A Rosenthal
Feb 19, 2021·Journal of Vascular Surgery·Baohui XuRonald L Dalman
Jul 21, 2020·AIDS Research and Human Retroviruses·Lena Al-HarthiDavid A Bennett
Apr 6, 2021·Molecular Genetics & Genomic Medicine·Nasser Pouladi, Sepehr Abdolahi
Apr 16, 2021·Circulation Research·Mina K ChungJoseph Loscalzo
May 21, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jie YinTongda Xu
May 27, 2021·Clinical Medicine Insights. Cardiology·Grigorios VoulalasDaryll Baker
Aug 24, 2021·Journal of Infection and Public Health·Maryam MeskiniMojgan Sheikhpour

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Datasets Mentioned

BETA
GSE136848
GSE139516

Software Mentioned

UMAP
R package Seurat
VlnPlot
FeaturePlot

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