Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2

Frontiers in Cell and Developmental Biology
Nancy AsharyDeepak Modi


Infection by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) results in the novel coronavirus disease COVID-19, which has posed a serious threat globally. Infection of SARS-CoV-2 during pregnancy is associated with complications such as preterm labor and premature rupture of membranes, and a proportion of neonates born to infected mothers are also positive for the virus. During pregnancy, the placental barrier protects the fetus from pathogens and ensures healthy development. To predict if the placenta is permissive to SARS-CoV-2, we utilized publicly available single-cell RNA-seq data to identify if the placental cells express the necessary factors required for infection. SARS-CoV-2 binding receptor ACE2 and the S protein priming protease TMPRSS2 are co-expressed by a subset of syncytiotrophoblasts (STB) in the first trimester and extravillous trophoblasts (EVT) in the second trimester human placenta. In addition, the non-canonical receptor BSG/CD147 and other proteases (CTSL, CTSB, and FURIN) are detected in most of the placental cells. Other coronavirus family receptors (ANPEP and DPP4) were also expressed in the first and second trimester placental cells. Additionally, the term placenta of multiple species ...Continue Reading


May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·T PushkarskyM Bukrinsky
Sep 30, 2006·Reproductive Biomedicine Online·Errol R Norwitz
Mar 20, 2010·American Journal of Reproductive Immunology : AJRI·Justine S FitzgeraldUdo R Markert
Sep 10, 2013·Human Reproduction·Cheuk-Lun LeePhilip C N Chiu
Jan 15, 2014·JAK-STAT·Pankaj SumanSatish Kumar Gupta
Jul 16, 2014·The International Journal of Developmental Biology·Michael J SoaresM A Karim Rumi
Jan 15, 2015·American Journal of Reproductive Immunology : AJRI·Michelle SilasiGil Mor
Sep 6, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia GiuglianoHugo R Rosen
Oct 6, 2015·Steroids·Federico MartinezOscar Flores-Herrera
Oct 8, 2015·Annual Review of Cell and Developmental Biology·Emin Maltepe, Susan J Fisher
Oct 23, 2015·American Journal of Reproductive Immunology : AJRI·Satish Kumar GuptaPiyush Chaudhary
Oct 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Stephen J RenaudMichael J Soares
Jan 13, 2016·American Journal of Reproductive Immunology : AJRI·Shipra SharmaDeepak Modi
Sep 2, 2016·PLoS Pathogens·Manalee Vishnu SurveAnirban Banerjee
Sep 9, 2016·Physiological Reviews·Graham J BurtonKent L Thornburg
Jun 24, 2017·Current Topics in Microbiology and Immunology·Adriaan H de WildeMartijn J van Hemert
Jan 19, 2018·Nature Communications·Alec J HirschDaniel N Streblow
Feb 3, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rulan BaiKazuhiko Imakawa
Feb 17, 2018·ELife·Alistair B RussellJesse D Bloom
Apr 13, 2018·Reproductive Sciences·Sharvari S Deshpande, Nafisa H Balasinor
Jun 17, 2018·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Sarah H AlfarajZiad A Memish
Sep 21, 2018·Frontiers in Cell and Developmental Biology·Quy H NguyenKai Kessenbrock
Nov 8, 2018·Science Advances·Hemant SuryawanshiZev Williams
Nov 16, 2018·Nature·Roser Vento-TormoSarah A Teichmann
Nov 30, 2018·Frontiers in Immunology·Jürgen PollheimerMartin Knöfler
Apr 15, 2019·Molecular and Cellular Endocrinology·Masashi UedaMasaki Mandai
May 28, 2019·Current Opinion in Cell Biology·Alberto T Gatta, Jeremy G Carlton
Jun 5, 2019·American Journal of Obstetrics and Gynecology·Ivo BrosensGiuseppe Benagiano
Sep 20, 2019·Nature Reviews. Genetics·Myriam HembergerWendy Dean
Nov 30, 2019·Development·Margherita Y Turco, Ashley Moffett
Jan 4, 2020·Molecular and Cellular Endocrinology·Yukiyasu Sato

❮ Previous
Next ❯


Dec 22, 2020·Frontiers in Medicine·Francesca SalamannaMilena Fini
Jan 14, 2021·Diagnostics·Yin Ping WongGeok Chin Tan
Feb 10, 2021·Journal of Medical Virology·C Merve Seymen
Jan 2, 2021·Biochemical and Biophysical Research Communications·Kathryn M Moore, Mehul S Suthar
Feb 26, 2021·Journal of Human Reproductive Sciences·Padma Rekha JirgeDeepak Modi
Mar 21, 2021·Cell·Joachim L Schultze, Anna C Aschenbrenner
Feb 28, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·M ZaighamP Tannenberg
Jun 4, 2021·Cell Metabolism·Xuming TangShuibing Chen
Jun 11, 2021·The American Journal of Pathology·Arthur ColsonFrédéric Debiève
Jun 12, 2021·Der Pathologe·T MenterE Bruder
Jun 23, 2021·Stem Cell Reviews and Reports·Mohammed AbdulhasanDaniel A Rappolee
Jul 13, 2021·Frontiers in Molecular Biosciences·Kseniia Sarieva, Simone Mayer
Jul 15, 2021·Scientific Reports·Mirella MouradYoel Sadovsky
Jun 24, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rahul K GajbhiyeDeepak N Modi
Jul 27, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Paulina Fuentes-ZacaríasDiana M Morales-Prieto
Aug 31, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Anya Lara ArthursClaire Trelford Roberts
Sep 7, 2021·Frontiers in Medicine·Penélope Saldanha MarinhoArnaldo Prata-Barbosa
Nov 26, 2021·Frontiers in Molecular Biosciences·Flávia Bessi ConstantinoLuis Antonio Justulin
Nov 10, 2021·Cell Reports Medicine·Amal FahmiMarco P Alves
Jan 20, 2022·Clinical Obstetrics and Gynecology·Margaret H KyleDani Dumitriu

❮ Previous
Next ❯

Datasets Mentioned


Methods Mentioned

Magnetic Activated Cell Sorting
electron microscopy

Software Mentioned

pheatmap R package
GraphPad Prism
Google Scholar
gplots R package

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.