Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

Biochemical and Biophysical Research Communications
Furong QiZheng Zhang


The new coronavirus (SARS-CoV-2) outbreak from December 2019 in Wuhan, Hubei, China, has been declared a global public health emergency. Angiotensin I converting enzyme 2 (ACE2), is the host receptor by SARS-CoV-2 to infect human cells. Although ACE2 is reported to be expressed in lung, liver, stomach, ileum, kidney and colon, its expressing levels are rather low, especially in the lung. SARS-CoV-2 may use co-receptors/auxiliary proteins as ACE2 partner to facilitate the virus entry. To identify the potential candidates, we explored the single cell gene expression atlas including 119 cell types of 13 human tissues and analyzed the single cell co-expression spectrum of 51 reported RNA virus receptors and 400 other membrane proteins. Consistent with other recent reports, we confirmed that ACE2 was mainly expressed in lung AT2, liver cholangiocyte, colon colonocytes, esophagus keratinocytes, ileum ECs, rectum ECs, stomach epithelial cells, and kidney proximal tubules. Intriguingly, we found that the candidate co-receptors, manifesting the most similar expression patterns with ACE2 across 13 human tissues, are all peptidases, including ANPEP, DPP4 and ENPEP. Among them, ANPEP and DPP4 are the known receptors for human CoVs, suggest...Continue Reading


Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Nathalie Chazal, Denis Gerlier
Jul 15, 2003·Journal of Virology·Paul AhlquistBilly T Dye
Jul 1, 2005·Cell Research·Andrea K PerryGenhong Cheng
Jul 12, 2008·Nature Reviews. Immunology·Philip J R Goulder, David I Watkins
Jun 6, 2009·Nature Reviews. Immunology·Ted H Hansen, Marlene Bouvier
Jan 24, 2015·Nature Reviews. Immunology·Finlay McNabAnne O'Garra
Aug 12, 2016·Nucleic Acids Research·Andrei L LomizeIrina D Pogozheva
Oct 24, 2018·Nature Communications·Sonya A MacParlandIan D McGilvray
Dec 7, 2018·JCI Insight·Karolyn A OetjenChristopher S Hourigan
Dec 18, 2018·American Journal of Respiratory and Critical Care Medicine·Paul A ReyfmanAlexander V Misharin
Jun 11, 2019·Cell·Tim StuartRahul Satija
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Andrew P VoigtRobert F Mullins
Nov 20, 2019·Nature Methods·Ilya KorsunskySoumya Raychaudhuri
Nov 23, 2019·The Journal of Experimental Medicine·Yalong WangYe-Guang Chen
Jan 4, 2020·Scientific Data·Jinling LiaoZengnan Mo

❮ Previous
Next ❯


Apr 17, 2020·Journal of Thrombosis and Thrombolysis·Richard C Becker
May 31, 2020·International Journal of Molecular Sciences·Francesca RossiFrancesca Punzo
Jun 17, 2020·Therapeutic Advances in Respiratory Disease·Corrado PelaiaGirolamo Pelaia
Jun 27, 2020·Ocular Immunology and Inflammation·Andrea LeonardiPaola Brun
Jul 4, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ulrike Schmidt, Theo Rein
May 15, 2020·European Journal of Clinical Investigation·Wiktor SmykMarcin Krawczyk
Jun 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeremy K Y YapAkiko Iwasaki
May 7, 2020·Journal of Medical Virology·Clemens LangeGünther Schlunck
Jun 3, 2020·Gut and Liver·Giovanni MonteleoneFederica Laudisi
Jun 15, 2020·Allergy·Carmen RiggioniCezmi A Akdis
Jun 17, 2020·European Journal of Gastroenterology & Hepatology·Muhammed YukselCigdem Arikan
Jul 25, 2020·Expert Review of Gastroenterology & Hepatology·Paola DongiovanniAnna Ludovica Fracanzani
May 13, 2020·Journal of Diabetes·Margaret F BassendineMark D Gorrell
Aug 12, 2020·Protein & Cell·Yingfeng ZhengWenru Su
Aug 19, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Omalla A OlwenyiSiddappa N Byrareddy
Jun 27, 2020·European Journal of Clinical Investigation·Piero PortincasaAgostino Di Ciaula
Aug 2, 2020·The FEBS Journal·Pu Xia, Anna Dubrovska
Aug 28, 2020·Open Biology·Vanessa WaznyChristine Cheung
Aug 28, 2020·Current Hypertension Reports·Leanne GrobanCarlos M Ferrario
Sep 5, 2020·Seminars in Liver Disease·Maria J Lizardo-ThiebaudNalu Navarro-Alvarez
Sep 8, 2020·Journal of Clinical Laboratory Analysis·Jinrui GaoZhihao Xu
Sep 15, 2020·The Journal of Experimental Medicine·Flavio Protasio VerasFernando Queiroz Cunha
Sep 26, 2020·Physiological Reports·Bahareh HajikhaniMehdi Mirsaeidi
Oct 3, 2020·Aging Cell·Didac SantesmassesVadim N Gladyshev
May 10, 2020·Cellular and Molecular Neurobiology·Juan M Saavedra
Jul 1, 2020·Therapeutic Advances in Gastroenterology·Song SuJie Liang
Jul 8, 2020·Cells·Nazzarena LabòGiovanna Tosato
Jul 30, 2020·Virologica Sinica·Zheng ZhangYousong Peng
Jul 12, 2020·Nature Medicine·Aakriti GuptaDonald W Landry
Sep 19, 2020·Journal of Cellular Physiology·Rajasekaran MahalingamRajarajan A Thandavarayan
Sep 26, 2020·Frontiers in Immunology·Hanaa Ahmed-HassanNamal P M Liyanage
Sep 25, 2020·JAMA : the Journal of the American Medical Association·Mohamad El MohebHaytham M A Kaafarani
Oct 2, 2020·The Journal of Experimental Medicine·Jack Major, Andreas Wack
Jul 16, 2020·International Journal of Molecular Sciences·Elena CampioneLuca Bianchi
Jul 3, 2020·Nature Communications·Arnar BreevoortMohammed A Mostajo-Radji

❮ Previous
Next ❯

Methods Mentioned


Software Mentioned

Seurat package

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.