Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time

Trends in Molecular Medicine
Dimitry OfengeimJunying Yuan

Abstract

Single-cell RNA sequencing (scRNA-seq) is an exciting new technology allowing the analysis of transcriptomes from individual cells, and is ideally suited to address the inherent complexity and dynamics of the central nervous system. scRNA-seq has already been applied to the study of molecular taxonomy of the brain. These works have paved the way to expanding our understanding of the nervous system and provide insights into cellular susceptibilities and molecular mechanisms in neurological and neurodegenerative diseases. We discuss recent progress and challenges in applying this technology to advance our understanding of the brain. We advocate the application of scRNA-seq in the discovery of targets and biomarkers as a new approach in developing novel therapeutics for the treatment of neurodegenerative diseases.

Citations

Sep 10, 2017·Cell and Tissue Research·Ting Zhou, Hiroaki Matsunami
May 1, 2018·Acta Neuropathologica·Bert M VerheijenFred W van Leeuwen
Mar 8, 2018·Stress : the International Journal on the Biology of Stress·Anand GururajanJuan Pablo Lopez
Sep 8, 2018·Annual Review of Genetics·Kenneth D Birnbaum
Jan 26, 2018·Nature Protocols·Ben KorinAsya Rolls
Sep 1, 2019·Current Alzheimer Research·Laura Trujillo-EstradaFrank M LaFerla
Mar 19, 2019·Frontiers in Genetics·Samantha L GoldmanChristopher E Mason
Jun 20, 2019·Frontiers in Neuroscience·Elizabeth M Rhea, William A Banks
May 8, 2018·Frontiers in Cell and Developmental Biology·Youjin HuYing Guo
Jun 21, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Viktoria RungelrathFrank R DeLeo
Nov 30, 2018·Frontiers in Immunology·Fatima Valdes-MoraDavid Gallego-Ortega
Oct 7, 2018·Cellular and Molecular Neurobiology·Onno C MeijerMarcel J M Schaaf
Jul 25, 2020·Nature Reviews. Neuroscience·Yun Young YimEric J Nestler
Apr 24, 2020·Laboratory animal research·Matthew BakerDoo-Sup Choi
Jul 22, 2019·Nature Communications·Kyoko WatanabeDanielle Posthuma
May 22, 2019·Nature Immunology·Evan DerUNKNOWN Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium
Oct 22, 2020·Immunity, Inflammation and Disease·Norwin KubickMichel-Edwar Mickael
Dec 22, 2020·Frontiers in Molecular Neuroscience·Davide Martino Coda, Johannes Gräff
Aug 3, 2021·The Journal of Clinical Investigation·Dongyin Guan, Mitchell A Lazar
Aug 31, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James A WisemanThomas I-H Park
Dec 11, 2021·Cell Proliferation·Yongxiang ZhangChengzhen Liang

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