Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development

Sean C BendallDana Pe'er


Tissue regeneration is an orchestrated progression of cells from an immature state to a mature one, conventionally represented as distinctive cell subsets. A continuum of transitional cell states exists between these discrete stages. We combine the depth of single-cell mass cytometry and an algorithm developed to leverage this continuum by aligning single cells of a given lineage onto a unified trajectory that accurately predicts the developmental path de novo. Applied to human B cell lymphopoiesis, the algorithm (termed Wanderlust) constructed trajectories spanning from hematopoietic stem cells through to naive B cells. This trajectory revealed nascent fractions of B cell progenitors and aligned them with developmentally cued regulatory signaling including IL-7/STAT5 and cellular events such as immunoglobulin rearrangement, highlighting checkpoints across which regulatory signals are rewired paralleling changes in cellular state. This study provides a comprehensive analysis of human B lymphopoiesis, laying a foundation to apply this approach to other tissues and "corrupted" developmental processes including cancer.


Apr 1, 1984·The Journal of Experimental Medicine·Richard R HardyL A Herzenberg
Jul 9, 1999·Immunology Letters·A RolinkFritz Melchers
Mar 17, 2004·Current Opinion in Immunology·Joonsoo Kang, Sandy D Der
Aug 30, 2008·Blood·T W LeBien, Thomas F Tedder
May 16, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·César Cobaleda, Isidro Sánchez-García
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eva SanzAntonio de-la-Hera
Oct 4, 2011·Nature Biotechnology·Peng QiuSylvia K Plevritis
Mar 17, 2012·Seminars in Immunology·Steven A Corfe, Christopher J Paige
May 12, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Harris G FienbergBernd Bodenmiller
Mar 21, 2013·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Rachel FinckSean C Bendall


Nov 5, 2014·Molecular Biology of the Cell·Oguzhan Atay, Jan M Skotheim
Nov 15, 2014·Nature Immunology·Jonathan M Irish
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Eugenio MarcoGuo-Cheng Yuan
Nov 10, 2015·European Journal of Immunology·Florian MairBurkhard Becher
Aug 16, 2014·Current Opinion in Biotechnology·Serena Di Palma, Bernd Bodenmiller
Dec 2, 2015·Immunology and Cell Biology·Valentina Proserpio, Tapio Lönnberg
Nov 19, 2015·Immunology and Cell Biology·Steven WoodhouseJasmin Fisher
Dec 18, 2014·Cell Stem Cell·Martin EtzrodtTimm Schroeder
May 28, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·C Bruce BagwellFrederic I Preffer
Nov 4, 2015·Immunology and Cell Biology·Ana Cvejic
Nov 25, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Katherine J NicholasSpyros A Kalams
Nov 14, 2015·Annual Review of Cell and Developmental Biology·Stefan Semrau, Alexander van Oudenaarden
Oct 10, 2015·Trends in Genetics : TIG·Assieh SaadatpourGuo-Cheng Yuan
Apr 8, 2016·Genome Biology·Rhonda Bacher, Christina Kendziorski
Aug 25, 2015·Nature Methods·Gabriele GutPrisca Liberali
Jun 27, 2015·Human Molecular Genetics·Quin F Wills, Adam J Mead
May 24, 2015·Bioinformatics·Laleh HaghverdiFabian J Theis
Apr 25, 2015·Drug Discovery Today·Araz A Raoof, Jeroen Aerssens
Oct 23, 2015·Transplantation·Robert W Hutchinson, James A Hutchinson
Jun 23, 2015·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Sean SimmonsBonnie Berger
Dec 24, 2014·Cell and Tissue Research·Robert Durruthy-Durruthy, Stefan Heller
May 17, 2015·Methods : a Companion to Methods in Enzymology·Kirsten E DigginsJonathan M Irish
May 23, 2015·Molecular Cell·Aleksandra A KolodziejczykSarah A Teichmann
May 11, 2015·Cell Stem Cell·Giacomo Donati, Fiona Watt
Mar 13, 2015·Blood·Berthold Göttgens
Mar 26, 2015·Frontiers in Oncology·Itamar Kanter, Tomer Kalisky
Apr 23, 2016·Science·Alison GallowayMartin Turner
Oct 14, 2014·Frontiers in Genetics·Mike Stein BarnkobLars Rønn Olsen
Apr 27, 2016·Current Opinion in Biotechnology·Deborah ChasmanSushmita Roy
Dec 3, 2014·Nature Reviews. Genetics·Prisca LiberaliLucas Pelkmans
May 4, 2016·The Journal of Experimental Medicine·Finola E MooreDavid M Langenau
May 8, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Allison R GreenplateJonathan M Irish
May 7, 2016·Cell·Matthew H Spitzer, Garry P Nolan
May 7, 2016·Bioinformatics·Aaron DiazArnold Kriegstein
May 15, 2016·Nucleic Acids Research·Zhicheng Ji, Hongkai Ji
May 22, 2016·Nucleic Acids Research·Gregory GiecoldGuo-Cheng Yuan
May 3, 2016·Current Opinion in Hematology·Marie PouzollesValérie S Zimmermann
May 24, 2016·Current Opinion in Hematology·Katrin Busch, Hans-Reimer Rodewald
Jun 21, 2016·Nature Reviews. Immunology·Yvan SaeysBart N Lambrecht
Jun 28, 2016·Cell Stem Cell·Dominic GrünAlexander van Oudenaarden
Jun 20, 2016·Trends in Biotechnology·Qin Bian, Patrick Cahan
Jul 15, 2016·Histochemistry and Cell Biology·Arkadiy K GolovAlexey A Gavrilov
Jun 19, 2016·Bioinformatics·John E Reid, Lorenz Wernisch
Jul 15, 2016·Cell Host & Microbe·Victoria A Green, Lucas Pelkmans
Jul 13, 2016·FEBS Letters·Leïla Perié, Ken R Duffy
Aug 30, 2016·Nature Methods·Laleh HaghverdiFabian J Theis
Sep 14, 2016·Current Opinion in Cell Biology·Thomas Höfer, Hans-Reimer Rodewald
Sep 13, 2016·Nature Reviews. Genetics·Naomi MorisAlfonso Martinez Arias
Oct 7, 2016·Frontiers in Genetics·Olivier B PoirionLana Garmire
Sep 26, 2016·Current Opinion in Cell Biology·Victoria Moignard, Berthold Göttgens
Sep 30, 2016·European Journal of Immunology·Robrecht CannoodtYvan Saeys
Aug 31, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Katja KleinsteuberBruce D Walker
Nov 9, 2016·Nature Biotechnology·Stavroula SkylakiTimm Schroeder
Nov 9, 2016·Nature Biotechnology·Allon WagnerNir Yosef
Jun 5, 2016·FEBS Letters·Fiona K HameyBerthold Göttgens
Dec 9, 2016·Nature Protocols·Rapolas ZilionisLinas Mazutis
Sep 12, 2015·Molecular Human Reproduction·Dicle YalcinHasan H Otu
Dec 23, 2016·Assay and Drug Development Technologies·Jia-Ren Lin
Nov 27, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S M KramsO M Martinez
Oct 23, 2015·PLoS Computational Biology·Hirenkumar K MakadiaRajanikanth Vadigepalli
Jul 15, 2015·PLoS Computational Biology·Yael KoremUri Alon
Dec 10, 2016·Cytometry. Part B, Clinical Cytometry·Yann AbrahamCaroline Gubser Keller
Jan 31, 2017·Nature Methods·Kirsten E DigginsJonathan M Irish
Jan 28, 2017·Current Opinion in Genetics & Development·Daphne Tsoucas, Guo-Cheng Yuan
Sep 24, 2016·PLoS Computational Biology·Hao ChenJinmiao Chen
Apr 11, 2017·Nature Reviews. Genetics·Sanjay M PrakadanDavid A Weitz
Apr 6, 2017·Bioinformatics·Sabrina RashidZiv Bar-Joseph
May 12, 2017·Chemistry, an Asian Journal·Lu HuangHongkai Wu
Sep 27, 2015·Molecular & Cellular Proteomics : MCP·Qiang TianNathan D Price
Jan 20, 2017·Nature·Amos Tanay, Aviv Regev
Jun 11, 2017·FEBS Letters·Ilaria LungerMichael A Rieger
Jun 6, 2017·Bioinformatics·Nikolaos K ChlisFabian J Theis
Mar 8, 2018·Nature·Christian MayerRahul Satija
Mar 13, 2018·Nature Methods·Ayelet AlpertShai S Shen-Orr
Mar 20, 2018·Nature Methods·Daniel EdsgärdRickard Sandberg
Feb 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Caleb WeinrebAllon M Klein
Apr 21, 2018·Annual Review of Immunology·Alexandra-Chloé VillaniNir Hacohen
Mar 8, 2018·The Journal of Experimental Medicine·Na LiFrits Koning
May 26, 2017·F1000Research·Malgorzata NowickaMark D Robinson
Sep 27, 2014·World Journal of Stem Cells·Michiko IchiiYuzuru Kanakura
Oct 11, 2017·ELife·James Alexander BriggsMarc W Kirschner
Aug 9, 2017·Nature Reviews. Immunology·Efthymia Papalexi, Rahul Satija
May 5, 2018·Genome Research·Giovanni IaconoHolger Heyn
Apr 28, 2018·Science·Jeffrey A FarrellAlexander F Schier
Nov 2, 2017·Briefings in Functional Genomics·Chung-Chau HonMichael J T Stubbington
Oct 14, 2017·Briefings in Functional Genomics·Aleksandra A Kolodziejczyk, Tapio Lönnberg
Dec 6, 2017·ELife·Aviv RegevHuman Cell Atlas Meeting Participants
Jul 28, 2018·Bioinformatics·Magdalena E StraußLorenz Wernisch
Jul 31, 2018·The FEBS Journal·Helena Todorov, Yvan Saeys
Sep 14, 2017·The Journal of Experimental Medicine·Stephen J LoughranAnthony R Green
Oct 3, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Lars R OlsenHolden T Maecker
Nov 6, 2018·The FEBS Journal·Aline Xavier da Silveira Dos Santos, Prisca Liberali
Nov 6, 2018·The FEBS Journal·Petter Brodin
Sep 8, 2018·Annual Review of Genetics·Kenneth D Birnbaum
Mar 8, 2016·F1000Research·Serena Liu, Cole Trapnell
Dec 13, 2018·PloS One·Ulrike Strittmatter-KellerTamás Schweighoffer
Jun 26, 2018·Bioinformatics·Kieran R Campbell, Christopher Yau
Feb 13, 2018·Nature Communications·Maria Anna RapsomanikiMaría Rodríguez Martínez
Mar 3, 2018·Nature Communications·Edroaldo Lummertz da RochaGeorge Q Daley
Oct 7, 2017·Science·Michael J T StubbingtonSarah A Teichmann
Feb 22, 2018·Nature·Betsabeh Khoramian TusiMerav Socolovsky
Apr 13, 2019·Immunological Reviews·Sandra Zehentmeier, João P Pereira
Dec 15, 2018·The FEBS Journal·Akshitkumar M MistryJonathan M Irish
May 1, 2019·Bioinformatics·Chieh Lin, Ziv Bar-Joseph
May 24, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Palak SekhriGregory K Behbehani
Jan 26, 2018·Nature Protocols·Ben KorinAsya Rolls
Jul 30, 2019·Immunological Reviews·Elad JacobyNirali N Shah
Apr 18, 2018·Molecular Systems Biology·Jonathan A GriffithsJohn C Marioni
Mar 17, 2018·Molecular Systems Biology·Shiwei ZhengRahul Satija
Mar 29, 2019·Molecular Systems Biology·Will MacnairManfred Claassen
Dec 17, 2016·Molecular Systems Biology·Jason YaoRoy Wollman
Jan 9, 2019·Cold Spring Harbor Perspectives in Medicine·Naishitha AnaparthyJames Hicks
Dec 1, 2017·Cell and Tissue Research·Lise J HarbomMichael J McConnell
Dec 8, 2016·Current Protocols in Chemical Biology·Jia-Ren LinPeter K Sorger
Nov 2, 2017·Current Protocols in Immunology·Thomas Myles AshhurstNicholas Jonathan Cole King
Nov 11, 2019·Life Science Alliance·Reema BaskarSean C Bendall
Dec 6, 2019·Journal of Leukocyte Biology·Gang XuZheng Zhang
Oct 23, 2019·Frontiers in Immunology·Patrick Günther, Joachim L Schultze
Dec 20, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Stefano PirròClaude Chelala
Oct 22, 2019·Immunological Reviews·Jennie A HamiltonJohn D Mountz
Dec 5, 2019·Nature Biotechnology·Kevin R MoonSmita Krishnaswamy
Feb 27, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kleio-Maria VerrouGeorgios Papoutsoglou
Feb 19, 2020·PLoS Computational Biology·Chieh LinZiv Bar-Joseph
Nov 3, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick M ReevesMark C Poznansky
Jan 15, 2020·Nature Methods·William S ChenSmita Krishnaswamy
Mar 6, 2020·Molecular & Cellular Proteomics : MCP·Xiao-Kang Lun, Bernd Bodenmiller
Nov 8, 2017·Oncotarget·Ignacio VarelaAlejandra Sanjuan-Pla
May 10, 2017·Genome Biology·Guo-Cheng YuanItay Tirosh
Dec 8, 2019·Nature Communications·Loukia G KaracostaSylvia K Plevritis
Apr 7, 2020·Current Protocols in Cytometry·Caroline E RoeJonathan M Irish
Jan 15, 2020·Cold Spring Harbor Perspectives in Biology·Iwo Kucinski, Berthold Göttgens
Jul 8, 2020·Briefings in Functional Genomics·Sara S Fonseca CostaJürgen A Ripperger
Jul 14, 2020·Bioinformatics·Helena TodorovYvan Saeys
Aug 25, 2020·PLoS Computational Biology·Xiaomei LiThuc Duy Le
Sep 18, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Hongjie Li
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·David PejoskiAnne-Sophie Beignon
Sep 2, 2020·Scandinavian Journal of Immunology·André SulenBergithe E Oftedal
Apr 4, 2017·Current Protocols in Molecular Biology·Nalin LeelatianJonathan M Irish
Apr 9, 2015·Cytometry. Part B, Clinical Cytometry·C Bruce BagwellFrederic I Preffer
Jul 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hannah G PolikowskyJonathan M Irish
Oct 22, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Alan D SternMarc R Birtwistle
Jun 10, 2017·Clinical and Translational Medicine·Raquel Cuevas-Diaz DuranJia Qian Wu
Jun 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Fiona K HameyBerthold Göttgens
Dec 20, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abigail K KimballEric T Clambey
Apr 29, 2018·Scientific Reports·Jessica ShakleeJop H van Berlo
Dec 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Lingxue ZhuKathryn Roeder
Sep 14, 2019·Hematology·Alí F Citalan-MadridMargarita L Martinez-Fierro
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Jul 30, 2019·Frontiers in Immunology·Subarna PalitChristina E Zielinski
Jan 8, 2020·Nature Methods·Alexander F Schier
Apr 9, 2020·Frontiers in Immunology·Lara GibelliniAndrea Cossarizza
Jun 27, 2020·Nucleic Acids Research·Yungang XuXiaobo Zhou
Jul 19, 2020·Journal of Clinical Immunology·Connie H LinManish J Butte
May 18, 2016·Nature Methods·Nikolay SamusikGarry P Nolan
Feb 24, 2017·SLAS Discovery·Albert GoughD Lansing Taylor
May 8, 2018·Frontiers in Immunology·Hassen KaredAnis Larbi
Jul 13, 2018·Frontiers in Immunology·Daniel J KunzKylie R James
Apr 19, 2018·Nature Reviews. Molecular Cell Biology·Blanca Pijuan-SalaBerthold Göttgens
Jul 19, 2018·Scientific Reports·Felix J HartmannSean C Bendall
Jun 20, 2018·BMC Genomics·Kelly StreetSandrine Dudoit
Nov 14, 2018·Bioinformatics·Christopher A PenfoldM Azim Surani
Sep 2, 2018·Nature Methods·J Gray CampBarbara Treutlein
Mar 14, 2019·Nucleic Acids Research·Hao DaiLuonan Chen
Apr 3, 2019·Nature Biotechnology·Wouter SaelensYvan Saeys
Jul 2, 2019·Frontiers in Immunology·Ananda L Roy
Jun 1, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Amir ErezGrégoire Altan-Bonnet
Feb 24, 2019·Cellular & Molecular Immunology·Haide ChenGuoji Guo
Mar 2, 2019·Nucleic Acids Research·Jun DingZiv Bar-Joseph
Jun 21, 2019·Molecular Systems Biology·Malte D Luecken, Fabian J Theis
Aug 30, 2019·Molecular Biology of the Cell·Jonah CoolAnanda L Roy
Nov 28, 2019·Epigenomes·Rahul R SinghRick J Jansen
Mar 20, 2020·Nature Communications·Shaoheng LiangKen Chen
Jun 13, 2020·Nature Communications·Anna KlimovskaiaMaximilian Nickel
Jan 23, 2017·Journal of Hematology & Oncology·Fang YeGuoji Guo
Sep 8, 2017·Nature Communications·Philipp EulenbergF Alexander Wolf
Jun 21, 2017·Nature Communications·Zehua LiuTing Chen
Dec 22, 2016·Nucleic Acids Research·Minzhe GuoYan Xu
Apr 4, 2017·Frontiers in Biology·Gabrielle Rushing, Rebecca A Ihrie
May 24, 2018·Nature Reviews. Nephrology·Andrew S Potter
Apr 1, 2017·Current Pharmacology Reports·Ying LiLi Cai
Nov 30, 2018·Frontiers in Immunology·Fatima Valdes-MoraDavid Gallego-Ortega
Jul 4, 2018·International Journal of Molecular Sciences·Mikael Sigvardsson
Feb 15, 2019·Cellular & Molecular Immunology·Anil DangiXunrong Luo
Jul 24, 2019·Nature Ecology & Evolution·Jordi van GestelAndreas Wagner
Dec 14, 2018·Frontiers in Cardiovascular Medicine·Andrea MassaiaMichela Noseda
Jun 30, 2019·Development·Aaron McKenna, James A Gagnon
Mar 14, 2019·Nature Communications·Samuel C KimmeySean C Bendall
Mar 23, 2019·Nature Biotechnology·Manu SettyDana Pe'er
Oct 13, 2019·Genome Biology·Yael BaranAmos Tanay
Jan 2, 2020·Nature Reviews. Rheumatology·Felix J Hartmann, Sean C Bendall
Jul 14, 2020·ELife·Nathan E Reticker-Flynn, Edgar G Engleman
Jun 3, 2020·Nature Reviews. Gastroenterology & Hepatology·Prakash RamachandranNeil C Henderson
Aug 12, 2020·Annual Review of Biomedical Data Science· Sagar, Dominic Grün
Jul 10, 2017·Cancer Immunology, Immunotherapy : CII·Mikael RousselThierry Fest
May 3, 2016·Nature Biotechnology·Manu SettyDana Pe'er
May 20, 2017·FEBS Letters·Raghd RostomGozde Kar
Sep 28, 2017·Scientific Reports·Stéphanie M C BruekersWilhelm T S Huck
Apr 18, 2017·Nature Cell Biology·Ermelinda PorpigliaHelen M Blau
Mar 17, 2017·Annual Review of Analytical Chemistry·Angela R WuYanyi Huang
Jul 25, 2017·Expert Review of Proteomics·Upendra K KarJulian P Whitelegge
Aug 10, 2018·Experimental & Molecular Medicine·Byungjin HwangDuhee Bang
Dec 19, 2018·Bioinformatics·Sumon AhmedAlexis Boukouvalas
Nov 5, 2019·Frontiers in Immunology·Ronald P SchuylerElena W Y Hsieh
Nov 7, 2019·World Journal of Stem Cells·Xiao Zhang, Lei Liu
Aug 1, 2019·Nature Methods·Mohammad LotfollahiFabian J Theis
Jul 15, 2020·Advanced Materials Technologies·Stefan HarmsenSanjiv S Gambhir
Apr 29, 2020·PLoS Computational Biology·Karren Dai YangCaroline Uhler
May 9, 2020·Communications Biology·Maeve O'HuallachainGarry P Nolan
Jul 6, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Michael J AlexanderPaul A Reyfman
Sep 29, 2018·Molecular & Cellular Oncology·Jolanda Sarno, Kara L Davis
Mar 17, 2018·Briefings in Functional Genomics·Peter Vegh, Muzlifah Haniffa
Apr 3, 2020·Nature Reviews. Genetics·Daniel E Wagner, Allon M Klein
Jul 19, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cariad Chester, Holden T Maecker
Feb 20, 2018·Frontiers in Neuroscience·Hyobin Jeong, Vijay K Tiwari
Oct 31, 2020·ERJ Open Research·Darcy E WagnerAmy L Ryan
Nov 12, 2020·International Journal of Molecular Sciences·Shintaro Yamada, Seitaro Nomura
Nov 27, 2020·Journal of the American Society of Nephrology : JASN·Christian HinzeKai M Schmidt-Ott
Jan 9, 2021·Cell Stem Cell·Patrick CahanChristine A Wells
Aug 11, 2020·Computational and Structural Biotechnology Journal·Xinlin HuJing Qin
Apr 24, 2020·Computational and Structural Biotechnology Journal·Paulina RybakowskaConcepción Marañón
Jun 20, 2020·Seminars in Cell & Developmental Biology·Ana Cordeiro GomesMaria Salomé Gomes
Sep 14, 2020·IScience·Maya M L Poon, Donna L Farber
Jan 28, 2021·RNA Biology·Aida Cardona-AlberichChristopher R Sibley
Jan 23, 2021·Briefings in Bioinformatics·Qianqian Song, Jing Su
Feb 2, 2021·Nucleic Acids Research·Ruben Chazarra-GilMartin Hemberg
Feb 6, 2021·Nature Communications·Ahmet F CoskunGarry P Nolan
Nov 3, 2020·Clinical and Translational Medicine·Ting ZhangXianting Ding
Nov 14, 2020·Nature Medicine·Isabel SchulienChristoph Neumann-Haefelin
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Xiao-Kang Lun, Bernd Bodenmiller
Feb 6, 2021·Biology·Daniel E Di Zeo-SánchezM Isabel Lucena
Nov 19, 2020·Molecular Systems Biology·Daniel SchwabeNikolaus Rajewsky
Feb 20, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Melissa CheungJon Petzing
Sep 24, 2020·Cell Reports·Rebecca LeylekJuliana Idoyaga

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STAT5b Transcription Factor
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