Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma.

Science Immunology
Grégory SeumoisPandurangan Vijayanand

Abstract

CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens play an important role in driving and dampening airway inflammation in patients with asthma. Until recently, direct, unbiased molecular analysis of allergen-reactive TH and Treg cells has not been possible. To better understand the diversity of these T cell subsets in allergy and asthma, we analyzed the single-cell transcriptome of ~50,000 house dust mite (HDM) allergen-reactive TH cells and Treg cells from asthmatics with HDM allergy and from three control groups: asthmatics without HDM allergy and nonasthmatics with and without HDM allergy. Our analyses show that HDM allergen-reactive TH and Treg cells are highly heterogeneous and certain subsets are quantitatively and qualitatively different in individuals with HDM-reactive asthma. The number of interleukin-9 (IL-9)-expressing HDM-reactive TH cells is greater in asthmatics with HDM allergy compared with nonasthmatics with HDM allergy, and this IL-9-expressing TH subset displays enhanced pathogenic properties. More HDM-reactive TH and Treg cells expressing the interferon response signature (THIFNR and TregIFNR) are present in asthmatics without HDM allergy compared with those with HDM alle...Continue Reading

References

Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·M LöhningT Kamradt
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·S H ArshadN F Adkinson
Jun 20, 1998·The Journal of Biological Chemistry·T YoshidaO Yoshie
Oct 8, 1999·The Journal of Clinical Investigation·H C Oettgen, R S Geha
Dec 10, 1999·Nature·D B Corry, F Kheradmand
Jan 4, 2001·The New England Journal of Medicine·A B Kay
Jan 11, 2001·The New England Journal of Medicine·A B Kay
Mar 27, 2001·The Journal of Cell Biology·J C StinchcombeG M Griffiths
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P MaestrelliUNKNOWN Regione Veneto Study Group
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brigitte G DornerRichard A Kroczek
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·F Runa AliA Barry Kay
Jan 10, 2004·Immunologic Research·Arthur I RobertsYufang Shi
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vivian TsevelekiLesley Probert
Feb 25, 2005·The Journal of Experimental Medicine·Malay MandalIannis Aifantis
Sep 28, 2005·Nature Medicine·Pratip K ChattopadhyayMario Roederer
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Nov 30, 2005·The Journal of Experimental Medicine·Ian P LewkowichMarsha Wills-Karp
Dec 2, 2005·The European Respiratory Journal·S N GeorasV Casolaro
Jun 7, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kenneth W FinnsonAnie Philip
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
Sep 26, 2006·Nature Reviews. Immunology·Mark LarchéRudolf Valenta
Nov 8, 2006·The Journal of Experimental Medicine·Deborah H StricklandPatrick G Holt
May 16, 2007·The Journal of Investigative Dermatology. Symposium Proceedings·Asifa S HaiderJames G Krueger
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle ThewissenPiet Stinissen
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie D LeechSarah E M Howie
Feb 8, 2008·The Journal of Allergy and Clinical Immunology·Päivi M SaloDarryl C Zeldin
Nov 19, 2008·The Journal of Allergy and Clinical Immunology·Annemarie Sykes, Sebastian L Johnston
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·John T SchroederAnja P Bieneman
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Mar 18, 2009·Bioinformatics·Cole TrapnellSteven L Salzberg
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jan 11, 2011·Immunity·Gretta L StriteskyMark H Kaplan
Jul 26, 2011·Trends in Immunology·Lisa G Gregory, Clare M Lloyd
Aug 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bhaskar UpadhyayaCalman Prussin
Dec 17, 2011·Journal of Biomedicine & Biotechnology·Nikki B Marshall, Susan L Swain
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Su-Yang LiuGenhong Cheng
Sep 11, 2012·Nature Immunology·Youjin LeeVijay K Kuchroo

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Citations

Jun 14, 2020·Science Immunology·Jonathan M Coquet
Sep 14, 2020·IScience·Maya M L Poon, Donna L Farber
Dec 15, 2020·Current Allergy and Asthma Reports·Gabija DrazdauskaitėMohamed H Shamji
Mar 13, 2021·Cell·Hamida Hammad, Bart N Lambrecht
Jul 27, 2021·Frontiers in Immunology·Guirong LiuHuilian Che
Aug 5, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Fengfei SunJing Liu
Aug 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·D Alejandro CanariaMatthew R Olson
Aug 21, 2021·European Journal of Immunology·Julie DeckersErika von Mutius
Sep 29, 2021·Molecular Aspects of Medicine·Ioana AgacheMohamed H Shamji
Nov 10, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hanan M OsmanMariam Onsy F Hanna
Dec 6, 2021·The Journal of Allergy and Clinical Immunology·Céline VandammeTuomas Virtanen
Nov 24, 2021·The Journal of Clinical Investigation·Brinda MonianJ Christopher Love

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