Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression

Annals of Surgery
S TodoW Marsh

Abstract

The efficacy for primary orthotopic liver transplantation of a new immunosuppressive agent, FK 506 (tacrolimus, Prograf, Fujisawa USA, Deerfield, IL), was determined. After 3 years of preclinical research, a clinical trial of FK 506 for orthotopic liver transplantation was begun in February 1989, first as a rescue therapy for patients with intractable rejection with conventional immunosuppression, then as a primary drug. Between August 1989 and December 1993, 1391 recipients (1188 adult and 203 pediatric) of primary liver allografts were treated with FK 506 from the outset. Results from these patients were analyzed and compared with those of 1212 historical control patients (971 adult and 241 pediatric) given cyclosporine-based immunosuppression. Actuarial survival at 4 years was 86.2% with FK 506 versus 65.5% with cyclosporine in the pediatric patients (p < 0.0000) and 71.4% versus 65.5% in the adults (p < 0.0005). The need for retransplantation was reduced significantly for FK 506 patients. Four-year graft survival was 77.0% with FK 506 versus 48.4% with cyclosporine in the pediatric patients (p < 0.0000), and 61.9% with FK 506 versus 51.4% with cyclosporine in the adult recipients (p < 0.0000). Regression analysis revealed t...Continue Reading

References

Jun 27, 1992·Lancet·T E StarzlM Trucco
Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
Jan 1, 1992·Annual Review of Immunology·N H Sigal, F J Dumont
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·I CallebautJ P Mornon
Jul 4, 1990·JAMA : the Journal of the American Medical Association·T E StarzlM Alessiani
Sep 1, 1990·Annals of Surgery·S TodoR Shapiro
Oct 28, 1989·Lancet·T E StarzlA Jain
Jul 30, 1981·The New England Journal of Medicine·T E StarzlG P Schröter
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T E StarzlJ J Fung

❮ Previous
Next ❯

Citations

Mar 10, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A B JainJ J Fung
Dec 31, 2003·Journal of the American College of Surgeons·Clyde F Barker, Larry R Kaiser
Mar 12, 1999·The Surgical Clinics of North America·A JainJ J Fung
Mar 12, 1999·The Surgical Clinics of North America·J Reyes, G V Mazariegos
Oct 27, 1997·Annals of Surgery·C F Barker
Dec 1, 1995·Therapeutic Drug Monitoring·J J Fung, T E Starzl
Dec 27, 1996·Transplantation·R ShapiroT E Starzl
Aug 27, 1997·Transplantation·A JainT E Starzl
Sep 26, 2001·Transplantation·R S RazaviG Mieli-Vergani
Jun 1, 1996·Journal of Clinical Pharmacy and Therapeutics·W Clark
Sep 1, 1995·Postgraduate Medical Journal·R M Jindal, I Popescu
Feb 5, 2010·Journal of Transplantation·Sandeep Mukherjee, Urmila Mukherjee
Mar 16, 2001·Expert Opinion on Pharmacotherapy·G CiancioJ Miller
Jul 5, 2005·Expert Opinion on Investigational Drugs·P Komolmit, M H Davies
Apr 10, 2002·Critical Care Nursing Clinics of North America·Terran W Sims, Elizabeth W Good
Jul 1, 1997·Journal of Pediatric Surgery·M McKeeP Colombani
Feb 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John FungBijan Eghtesad
Aug 26, 1998·Therapeutic Drug Monitoring·M MorenoP Jara
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Y Calne
Jun 17, 2020·Transplantation·Song C Ong, Robert S Gaston

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.