Abstract
Partial breast irradiation using intraoperative radiotherapy (IORT) after breast-conserving surgery could be sufficient for a selected group of breast cancer patients. We report the results of a cohort of patients from a single center treated as part of the randomized phase-3 TARGIT-A trial. Patients (≥50 years) with cT1 cN0 cM0 and invasive ductal histology on biopsy were randomized between IORT with 20 Gy (arm-A) or postoperative whole-breast RT (WBRT) up to 56 Gy in 2 Gy fractions (arm-B). Postoperatively, patients in arm-A with multifocality, lymphovascular invasion, nodal invasion, extensive intraductal component, invasive lobular carcinoma, or resection margins <1 cm received additional postoperative WBRT. Between 2002 and 2012, 184 patients were randomized, of whom 90 in arm-A and 90 in arm-B were evaluated. Median follow-up was 8.5 years. The 5‑year overall survival was 94.4% in arm-A and 93.3% in arm-B (p = 0.73). Two local recurrences were observed: one at 70.3 months in an arm-A patient who received IORT + WBRT and another at 4.5 months in an arm-B patient who refused all forms of adjuvant treatment, thus resulting in a 5-year local recurrence of 0% in arm-A and 1.1% in arm-B. The 5‑year in-breast recurrence (outside...Continue Reading
References
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U VeronesiR Zucali
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard FisherUNKNOWN National Surgical Adjuvant Breast and Bowel Project
Dec 20, 2005·Lancet·M ClarkeUNKNOWN Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Nov 28, 2007·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marie-Luise Sautter-BihlUNKNOWN German Cancer Society
Feb 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Csaba PolgárUNKNOWN GEC-ESTRO breast cancer working group
Jun 24, 2010·Lancet·Jayant S VaidyaMichael Baum
Oct 25, 2011·Lancet·S DarbyR Peto
May 10, 2012·BMC Cancer·Christian NeumaierWenz Frederik
Jul 31, 2012·Breast Cancer Research and Treatment·Elena SperkFrederik Wenz
Mar 26, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R W BlameyS E Pinder
May 22, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin S HughesWilliam C Wood
Jul 24, 2013·Breast Cancer Research and Treatment·Mohammed R S KeshtgarDavid J Joseph
Nov 15, 2013·Lancet·Jayant S VaidyaUNKNOWN TARGIT trialists' group
Feb 1, 2015·The Lancet Oncology·Ian H KunklerUNKNOWN PRIME II investigators
May 11, 2016·Annals of Surgical Oncology·Stephanie A ValenteStephen R Grobmyer
Oct 1, 2016·Health Technology Assessment : HTA·Jayant S VaidyaMichael Baum
Nov 22, 2016·Practical Radiation Oncology·Candace CorreaJay R Harris
Mar 25, 2017·Radiation Oncology·Christiane MatuschekWilfried Budach
Apr 15, 2018·Radiation Oncology·Tammy CoricaJayant S Vaidya
Citations
Oct 31, 2019·Japanese Journal of Clinical Oncology·Yin MiRuitai Fan
Feb 23, 2020·Cancers·Sören SchnellhardtLuitpold Distel
Aug 20, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stefan StefanovicBenjamin Tuschy
May 1, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·V StrnadUNKNOWN Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)
Apr 23, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jin MengZhaozhi Yang
Jan 9, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Xinzhuo WangVincent Vinh-Hung
Jan 13, 2021·Annals of Surgical Oncology·Stephanie A ValenteStephen R Grobmyer
Nov 3, 2020·Frontiers in Oncology·Yin MiXiaoxiao Zuo
Dec 16, 2020·Brachytherapy·Matthew N MillsRoberto Diaz
Nov 7, 2020·International Journal of Molecular Sciences·Sören SchnellhardtLuitpold Distel
Jan 22, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gerd FastnerMichael Gnant
Jan 20, 2022·Cancer Communications·Xin WangXiang Wang