Single chain observation on collapse transition in giant DNA induced by negatively-charged polymer

Biochemical and Biophysical Research Communications
Y Ichiba, K Yoshikawa

Abstract

Poly-glutamic acid, a polyanion, has been shown to induce the all-or-none collapse transition in individual duplex DNAs from an elongated coil into a collapsed compact state, through the observation of single chains by fluorescence microscopy. This experimental finding is discussed in relation to the change in the higher-order structure of DNAs in the cytoplasmic space induced by a change in the concentration of polyanions, such as mRNA, as a possible route for feedback in gene expression.

References

Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·M YanagidaI Katsura

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