Single chain precursor prohaptoglobin promotes angiogenesis by upregulating expression of vascular endothelial growth factor (VEGF) and VEGF receptor2

FEBS Letters
Mi-Kyung OhIn-Sook Kim

Abstract

Prohaptoglobin (proHp) is processed into mature haptoglobin via site-specific cleavage. Although haptoglobin has been well studied, the functions of proHp remain unclear. We investigated the angiogenic action of proHp in endothelial cells, demonstrating that proHp upregulated vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) expression and endothelial sprouting and branching. ProHp-induced sprouting was attenuated by a VEGFR2 inhibitor. Moreover, proHp was detected in sera of cancer patients by immunoprecipitation and Western blot. These findings indicate that proHp promotes angiogenesis via VEGF/VEGFR2 signalling, and serum proHp level may be a useful biomarker for diseases associated with angiogenesis.

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Citations

May 21, 2016·Future Cardiology·Karen L Graves, David J Vigerust
Mar 19, 2014·Reproductive Toxicology·Malin HelmestamMatts Olovsson
Jul 15, 2020·Molecular Aspects of Medicine·Alessandra di MasiPaolo Ascenzi
Apr 17, 2021·Biomedit︠s︡inskai︠a︡ khimii︠a︡·S N Naryzhny, O K Legina
Jul 3, 2021·International Journal of Molecular Sciences·Stanislav NaryzhnyRimma Pantina
Aug 24, 2021·Biochemistry (Moscow) Supplement. Series B, Biomedical Chemistry·S N Naryzny, O K Legina

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