PMID: 6172148Dec 7, 1981Paper

Single channel properties of D-Leu2-gramicidin A. Side chain modulation of channel lifetime

Biochimica Et Biophysica Acta
R J BradleyD W Urry

Abstract

The channel forming properties of synthetic gramicidin A and DLeu2-gramicidin A were compared in black lipid membranes. The most probable single channel conductance was identical for both derivatives but in each case a distribution of smaller channel sizes was observed. However, the lifetime of the channel formed by DLeu2-gramicidin A was considerably shorter than for gramicidin A. The DLeu2 substitution is considered to interfere with the head to head hydrogen bonding which forms the conducting dimer, thus destabilizing the dimeric structure of the channel and reducing the lifetime. This represents the first demonstration of side-chain modulation of channel lifetime.

References

Jan 21, 1976·Biochimica Et Biophysica Acta·E BambergP Läuger
Mar 17, 1977·Biochimica Et Biophysica Acta·E Bamberg, K Janko
Feb 24, 1977·The Journal of Membrane Biology·H J ApellP Läuger
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E BambergH Alpes
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S WeinsteinW Veatch
Jun 9, 1976·Journal of the American Chemical Society·J S BalcerskiC Toniolo
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D W Urry
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Mar 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D W Urry

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Citations

Jul 18, 1983·Biochemical and Biophysical Research Communications·D W UrryK U Prasad
Sep 1, 1985·International Journal of Peptide and Protein Research·L B Weiss, R E Koeppe
Jan 1, 1983·International Journal of Peptide and Protein Research·D W UrryK U Prasad

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