Single-channel properties of I K,slow1 and I K,slow2 in mouse ventricular myocytes

Pflügers Archiv : European journal of physiology
Gong Xin LiuGideon Koren

Abstract

I K,slow1 and I K,slow2 are two important voltage-gated potassium (K+) currents expressed in mouse ventricular myocytes. However, their properties at the single-channel level have not been characterized. In this paper, we report two new single K+ channels, mK1 and mK2, in myocytes isolated from mouse ventricles and their possible correlation with the macroscopic currents I K,slow1 and I K,slow2. The conductance of mK1 and mK2 was 24 and 17 pS, respectively. Ensemble-averaged current demonstrated an inactivation time constant of 400 to 500 ms for mK1 compared with 1,300 to 2,000 ms for mK2. The mK1 channel was more sensitive than the MK2 channel to the K channel blocker 4-AP. In myocytes isolated from Kv1DN mice with functional knock out of the Kv1.5 channel, mK1 was not detectable but mK2 was present. Our data suggest that the newly characterized K+ channels, mK1 and mK2, likely correspond to the macroscopic currents of I K,slow1 and I K,slow2, respectively.

References

Jul 1, 1997·Circulation Research·L Wang, H J Duff
Apr 16, 1998·Pflügers Archiv : European journal of physiology·Y Liu, R H Joho
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LondonG Koren
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Nov 27, 1999·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·J S Mitcheson, M C Sanguinetti
Nov 27, 1999·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·S NattelZ Wang
Dec 22, 1999·The Journal of Physiology·W GuoJ M Nerbonne
Dec 2, 2000·The Journal of Physiology·E Bou-AbboudJ M Nerbonne
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H LiJ M Nerbonne
Jan 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jun ZhouGideon Koren
Jan 28, 2003·Biophysical Journal·Mohammad Shahidullah, Manuel Covarrubias
Oct 7, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Huilin LiJeanne M Nerbonne

❮ Previous
Next ❯

Citations

Jun 25, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Denis V AbramochkinLeonid V Rosenshtraukh
Jun 26, 2020·Frontiers in Pharmacology·István BaczkóKatja E Odening

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.