Single channel recordings from human cardiac sarcoplasmic reticulum.

Circulation Research
S R Holmberg, A J Williams

Abstract

Native membrane vesicles of human cardiac sarcoplasmic reticulum have been fused with artificial lipid bilayers to obtain recordings of single chloride and calcium release channels. Tissue was obtained from the explanted hearts of patients with end-stage cardiac failure undergoing heart transplantation. Although previous studies of calcium uptake and release have shown that the function of the sarcoplasmic reticulum is abnormal in end-stage cardiac failure, the basic properties of the channels are similar to those reported for equivalent channels from normal animal tissue.

References

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Citations

Jan 1, 1997·Basic Research in Cardiology·G HasenfussH Just
Aug 1, 1995·Cardiovascular Drugs and Therapy·J K GwathmeyR J Hajjar
Jan 1, 1992·Bulletin of Mathematical Biology·A Y WongJ B Bassingthwaighthe
Jan 1, 1997·Progress in Biophysics and Molecular Biology·J I Kourie
Dec 22, 1999·Annals of the New York Academy of Sciences·S E LehnartG Hasenfuss
Jan 9, 1992·Biochemical Pharmacology·W G Nayler
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Gerd Hasenfuss, Burkert Pieske
Jun 6, 1998·Cardiovascular Research·G Hasenfuss
Feb 1, 1992·Journal of Muscle Research and Cell Motility·A J Williams
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M MeyerW H Dillmann
Jul 1, 1996·Molecular and Cellular Biochemistry·W SchillingerG Hasenfuss

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