Single-Chip Dynamic Nuclear Polarization Microsystem

Analytical Chemistry
Nergiz Sahin SolmazG. Boero

Abstract

Integration of the sensitivity-relevant electronics of nuclear magnetic resonance (NMR) and electron spin resonance (ESR) spectrometers on a single chip is a promising approach to improve the limit of detection, especially for samples in the nanoliter and subnanoliter range. Here, we demonstrate the cointegration on a single silicon chip of the front-end electronics of NMR and ESR detectors. The excitation/detection planar spiral microcoils of the NMR and ESR detectors are concentric and interrogate the same sample volume. This combination of sensors allows one to perform dynamic nuclear polarization (DNP) experiments using a single-chip-integrated microsystem having an area of about 2 mm2. In particular, we report 1H DNP-enhanced NMR experiments on liquid samples having a volume of about 1 nL performed at 10.7 GHz(ESR)/16 MHz(NMR). NMR enhancements as large as 50 are achieved on TEMPOL/H2O solutions at room temperature. The use of state-of-the-art submicrometer integrated circuit technologies should allow the future extension of the single-chip DNP microsystem approach proposed here up the THz(ESR)/GHz(NMR) region, corresponding to the strongest static magnetic fields currently available. Particularly interesting is the possib...Continue Reading

References

Dec 26, 2001·Chemical Reviews·Michael E. LaceyJonathan V. Sweedler
Feb 16, 2002·Journal of Magnetic Resonance·Kevin R Minard, Robert A Wind
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Sep 27, 2003·Journal of Magnetic Resonance·C MassinR S Popovic
Feb 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Evan R McCarneySongi Han
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yael MaguireNeil Gershenfeld
Jun 10, 1994·Science·D RugarR D Kendrick
Feb 26, 2008·Journal of the American Chemical Society·Peter HöferMarina Bennati
Oct 23, 2008·Analytical Chemistry·Hans Georg KrojanskiRoland Hergenröder
Dec 3, 2008·The Review of Scientific Instruments·T Yalcin, G Boero
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·C L DegenD Rugar
Mar 27, 2009·Journal of the American Chemical Society·Jacob BartArno P M Kentgens
Oct 20, 2009·Journal of Magnetic Resonance·Jens AndersGiovanni Boero
Jan 25, 2011·Journal of Magnetic Resonance·Jens AndersGiovanni Boero
Nov 10, 2011·Physical Chemistry Chemical Physics : PCCP·Maria-Teresa TürkeMarina Bennati
Dec 3, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens AndersGiovanni Boero
Mar 13, 2012·Journal of Magnetic Resonance·Jens AndersGiovanni Boero
May 15, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·C GriesingerT F Prisner
Nov 28, 2013·Annual Review of Physical Chemistry·Romana SchirhaglChristian L Degen
Apr 4, 2014·Physical Chemistry Chemical Physics : PCCP·Nikolay EnkinMarina Bennati
Jul 6, 2014·Reports on Progress in Physics·Charles P Slichter
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Dongwan HaDonhee Ham
Sep 28, 2014·Journal of Magnetic Resonance·Gabriele GualcoGiovanni Boero
May 3, 2015·The Review of Scientific Instruments·Marco GrisiGiovanni Boero
Jan 13, 2016·Journal of Magnetic Resonance·Graeme FinchMarcel Utz
Mar 25, 2016·Journal of Magnetic Resonance·Jens AndersGiovanni Boero
Mar 21, 2017·Scientific Reports·Marco GrisiGiovanni Boero
Apr 8, 2017·Journal of Magnetic Resonance·Alessandro V MatheoudGiovanni Boero
Oct 13, 2017·Physical Chemistry Chemical Physics : PCCP·Ying ChenNancy M Washton
Jan 3, 2018·IEEE Transactions on Biomedical Circuits and Systems·Benjamin SporrerQiuting Huang
Feb 27, 2018·Analytical Chemistry·Bertrand PlainchontPatrick Giraudeau
Mar 16, 2018·Nature·David R GlennRonald L Walsworth
May 10, 2018·PloS One·E MontinaroG Boero
Jul 14, 2018·Journal of Magnetic Resonance·Alessandro V MatheoudGiovanni Boero
Dec 12, 2018·Journal of Magnetic Resonance·Sebastian SchnozBeat H Meier
Feb 3, 2019·The Review of Scientific Instruments·Marco GrisiGiovanni Boero
Apr 17, 2019·Nature Communications·Karel KouřilBenno Meier
May 31, 2019·Journal of the American Chemical Society·James EillsMarcel Utz
Jul 23, 2019·Journal of Magnetic Resonance·Robert G GriffinRichard J Temkin
Nov 27, 2019·Nature Methods·Jonas HandwerkerKlaus Scheffler
Jan 3, 2020·Analytical Chemistry·Ka-Meng LeiDonhee Ham

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Citations

Feb 27, 2021·Scientific Reports·Sebastian Z KissJan G Korvink
May 8, 2021·The Journal of Physical Chemistry. B·Nandita Abhyankar, Veronika Szalai

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