PMID: 6995132Jun 1, 1980Paper

Single daily dose penbutolol in the treatment of hypertension: a double blind crossover comparison with propranolol

European Journal of Clinical Pharmacology
M M Kubik, G W Hanks

Abstract

Penbutolol is a potent long-acting non-cardioselective beta-adrenergic blocker with partial agonist activity. A double-blind cross-over comparison of penbutolol given in a single daily dose and propranolol given twice daily in the treatment of ambulant patients with moderate hypertension is described. Fourteen patients completed the study and were treated with each drug for 12 weeks. Penbutolol in daily doses of 20-120 mg and propranolol in daily doses of 80-400 mg produced similar significant reductions in both supine and erect blood pressure. Penbutolol did not reduce heart rate to the same extent as propranolol, in equivalent doses. Penbutolol appears to produce adequate control of moderate hypertension when administered once a day, and this effect appears to be equivalent to divided doses of propranolol. No serious adverse effects were reported, although one patient receiving penbutolol experienced severe eye pains at a dose of 40 mg which resolved on crossing over to treatment with propranolol.

References

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Citations

Jun 1, 1990·Journal of Clinical Pharmacology·C P VenterW J du Plooy
Jun 1, 1989·The American Journal of Cardiology·J A Schoenberger
Nov 1, 1983·British Journal of Clinical Pharmacology·B SilkeS H Taylor
Jul 1, 1988·Journal of Veterinary Internal Medicine·M E PetersonA I Hurvitz
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Leslie HearnR Andrew Moore
Nov 28, 2013·The Cochrane Database of Systematic Reviews·Sheena DerryR Andrew Moore
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Related Concepts

Antihypertensive Agents
Diastolic Blood Pressure
Clinical Trials
Double-Blind Method
Drug Administration Schedule
Hypertensive Disease
Betapressin
Propanolamines
Rexigen
Pulse Taking

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