PMID: 6411390Jun 1, 1983Paper

Single daily dose short term carbimazole therapy for hyperthyroid Graves' disease

Clinical Endocrinology
I A MacFarlaneC G Beardwell

Abstract

Twenty-one patients with hyperthyroid Graves' disease were treated with carbimazole 30 mg daily, given as a single dose. Propranolol was also given for the first 3 weeks. All became clinically euthyroid with normal serum thyroxine (T4) levels, usually within 1-3 months. Patients with large goitres and raised serum alkaline phosphatase concentrations took longer to respond. In 19 patients a positive thyroid stimulating hormone (TSH) response to intravenous thyrotrophin releasing hormone (TRH) developed. Carbimazole was stopped soon after (median time of treatment 18 weeks, range 9-41 weeks) and 18 patients have been followed. Seven of these (39%) have remained in remission from hyperthyroidism for more than one year (median 77 weeks). Carbimazole 30 mg once daily is a convenient and effective treatment for hyperthyroid Graves' disease. Many patients will achieve prolonged remissions if treatment is stopped when serum T3 and T4 levels are in the low-normal range, usually 2-4 months after clinical euthyroidism has been reached.

References

Jul 28, 1977·The New England Journal of Medicine·M A GreerD J Bouma
Feb 1, 1979·Annals of Internal Medicine·D S CooperG H Daniels
Jan 25, 1979·The New England Journal of Medicine·J SherwoodM Garcia
Aug 7, 1980·The New England Journal of Medicine·A M McGregorR Hall
Apr 1, 1980·Annals of Internal Medicine·H TamaiS Nagataki

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Citations

Mar 1, 1987·Clinical Pediatrics·S H TanR Uma
Jul 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·R TempleC N Hales
Aug 4, 2004·Journal of Bioinformatics and Computational Biology·Tero AittokallioRiitta Lahesmaa
Jun 2, 2020·Frontiers in Endocrinology·Ali AbbaraWaljit S Dhillo
Nov 22, 1984·The New England Journal of Medicine·D S Cooper

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