Single-donor fibrin sealant for repair of urethrocutaneous fistulae following multiple hypospadias and epispadias repairs

Journal of Pediatric Urology
Abdol-Mohammad KajbafzadehMohammad Javad Mohseni

Abstract

To evaluate the efficacy of fibrin sealant for repair of urethrocutaneous fistula after multiple failed hypospadias and epispadias surgeries. The study population comprised 11 boys (mean age 12.18 years) with history of hypospadias or epispadias and at least two failed fistula repair operations leading to recurrent urethrocutaneous fistula. During the operation, single-donor fibrin glue, either from the patient (7) or a parent (4), was applied over the suture lines and beneath the skin. A urethral catheter was kept in place for 7-10 days. Follow up ranged from 6 to 24 months (mean 12.63 months). Nine patients had an uneventful postoperative course. In one patient with a large fistula, partial wound dehiscence occurred. In another patient with complete hypospadias, hematoma formation caused skin dehiscence but the urethra remained intact. Both cases recovered after 6 months with no further intervention. No fistula recurrence was reported during follow up. Single-donor fibrin glue could be a useful adjunct to surgical management of patients after multiple failed attempts at hypospadias or epispadias fistula repair. Moreover, this product improves the safety margin regarding the risk of disease transmission.

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Citations

Mar 13, 2014·International Urology and Nephrology·Abdol-Mohammad KajbafzadehMohammad Javad Mohseni
May 13, 2015·Journal of Pediatric Urology·M CakmakT Soyer
Dec 17, 2014·Advanced Drug Delivery Reviews·Neethu NinanYves Grohens
Dec 10, 2013·Journal of Pediatric Surgery·Tutku SoyerMurat Çakmak
Feb 6, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Abdelaziz Yehya MahmoudMohamed A Baky Fahmy
Oct 3, 2012·Current Opinion in Urology·Antonio MacedoValdemar Ortiz
May 10, 2012·International Wound Journal·Tutku SoyerÜçler Kisa

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