Single-dose and multidose prophylaxis in vaginal hysterectomy: a comparison of sodium cephalothin and metronidazole

American Journal of Obstetrics and Gynecology
K A HamodM B Dillon

Abstract

A total of 79 patients underwent vaginal hysterectomy and were randomly assigned to three regimens of prophylactic antibiotics: multidose intravenous sodium cephalothin, single-dose intravenous sodium cephalothin, and single-dose oral metronidazole. Control groups were selected from two previous studies conducted at our institution. The incidence rates of infectious morbidity following all three regimens of antibiotics were substantially lower than in the control groups. There was no statistically significant difference in the incidence of standard febrile morbidity and serious pelvic infections among the three groups. The fever index was lowest in the single-dose sodium cephalothin group.

Citations

Dec 14, 1990·Pharmaceutisch Weekblad. Scientific Edition·F M KauerW L Manson
Jun 12, 1998·The Australian and New Zealand Journal of Surgery·M McDonaldA Forbes
Jun 22, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·T H I BrummerP Härkki
Mar 7, 2013·Surgical Infections·Dale W BratzlerSociety for Healthcare Epidemiology of America (SHEA)
Nov 20, 1980·The New England Journal of Medicine·J Koch-Weser, P Goldman
Dec 22, 2006·Expert Review of Anti-infective Therapy·William J Ledger

Related Concepts

Bacterial Infections
Bacteroides
Ceftina
Alkalescens-Dispar Group
Fever
Hysterectomy
Vaginal Hysterectomy
Bayer 5360
Streptococcus
Surgical Wound Infection

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Australian & New Zealand Journal of Obstetrics & Gynaecology
J L Lander, S J Steigrad
International Journal of Clinical Pharmacology, Therapy, and Toxicology
D B EfflerA A Giambartolomei
© 2021 Meta ULC. All rights reserved