Single dose cefazolin prophylaxis for postcesarean infections: before vs. after cord clamping

The Journal of Maternal-fetal Medicine
J R WaxJ F Smith

Abstract

The objective of this study was to test the hypothesis that 1 g of cefazolin administered preoperatively is no more effective than the same dose administered after cord clamping in preventing postcesarean infectious morbidity. Ninety consecutive laboring subjects undergoing cesarean delivery at > or = 37 weeks gestation were randomized by computer to receive 1 g of cefazolin intravenously preoperatively or after cord clamping in a double-blinded, placebo-controlled study. The 2 groups were compared for differences in maternal and neonatal demographics, and intrapartum and operative characteristics associated with postcesarean infection. Primary maternal outcome variables were endometritis or wound infection. Secondary outcomes included intra-abdominal abscess formation, septic pelvic thrombophlebitis, pneumonia, or urinary tract infection. Neonatal outcomes included sepsis screens, sepsis, pneumonia, and meningitis. Subjects were followed 6 weeks postoperatively for late complications. Subjects receiving cefazolin preoperatively or after cord clamping had similar maternal and neonatal demographics, and intrapartum and operative characteristics. One patient in the former group experienced both endometritis and wound infection. I...Continue Reading

Citations

Jan 22, 2010·The New England Journal of Medicine·Rayna Clay, William Camann
Mar 21, 2009·Obstetrics and Gynecology·Alan T N TitaWilliam W Andrews
Dec 2, 2010·BMC Infectious Diseases·Eleftherios ZiogosKyriaki Kanellakopoulou
May 25, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·C FrancisE A Strand
Nov 27, 2008·Archives of Gynecology and Obstetrics·Gokhan YildirimYavuz Ceylan
Nov 29, 2001·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·M C Normand, E G Damato
Mar 15, 2011·Contraception·Sharon L AchillesUNKNOWN Society of Family Planning
Sep 22, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·E BoselliB Allaouchiche
Nov 7, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·H Baaqeel, R Baaqeel
Dec 17, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·R F LamontR Romero
Jul 24, 2013·The Journal of Obstetrics and Gynaecology Research·Nabendu BhattacharjeeSamir Chandra Ghoshroy
Mar 8, 2013·American Journal of Obstetrics and Gynecology·Joshua D DahlkeSuneet P Chauhan
Sep 6, 2008·American Journal of Obstetrics and Gynecology·Maged M CostantineGeorge R Saade
Nov 2, 2005·American Journal of Obstetrics and Gynecology·Vincenzo BerghellaSuneet P Chauhan
Dec 8, 2017·Acta Obstetricia Et Gynecologica Scandinavica·Claudia BolligChristine M Schmucker
Nov 18, 2014·The Cochrane Database of Systematic Reviews·Gillian M I GyteJuan C Vazquez
Dec 6, 2014·The Cochrane Database of Systematic Reviews·A Dhanya MackeenJason K Baxter
Nov 13, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sumanth GandraRamanan Laxminarayan

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