PMID: 2105115Jan 6, 1990Paper

Single dose cefotaxime plus metronidazole versus three dose cefuroxime plus metronidazole as prophylaxis against wound infection in colorectal surgery: multicentre prospective randomised study

BMJ : British Medical Journal
D C Rowe-JonesD S Cole

Abstract

To establish whether a single preoperative dose of cefotaxime plus metronidazole was as effective as a standard three dose regimen of cefuroxime plus metronidazole in preventing wound infection after colorectal surgery. Prospective randomised allocation to one of two prophylactic antibiotic regimens in a parallel group trial. Group sequential analyses of each 250 patients were performed. 14 District general and teaching hospitals. 1018 Adults having colorectal operations were randomised, of whom 943 were evaluated. Demographic features, conditions requiring surgery, and operative procedures were similar in the two groups. Most patients had surgery for carcinoma of the colon or rectum. Group 1 received cefotaxime 1 g intravenously plus metronidazole 500 mg intravenously preoperatively. Group 2 received cefuroxime 1.5 g intravenously plus metronidazole 500 mg intravenously preoperatively, followed by cefuroxime 750 mg intravenously plus metronidazole 500 mg intravenously eight hours and 16 hours postoperatively. Development of surgical wound infection (as evidenced by the presence of pus), death, or discharge from hospital. Wound condition was scored on a five point scale on alternate days until discharge or for up to 20 days pos...Continue Reading

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Citations

Mar 1, 1993·World Journal of Surgery·W T Morris
Jul 5, 2002·World Journal of Surgery·Gerald T McGrealH Paul Redmond
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