Single-dose cefuroxime in the prophylaxis of abdominal wound sepsis

Current Medical Research and Opinion
W G Lambert, B M Mullinger


A double-blind study was carried out to investigate the prophylactic use of single-dose cefuroxime in elective abdominal surgery. Twenty-three patients received 1.5 g cefuroxime by intravenous injection immediately prior to induction of anaesthesia; 24 patients received no antibiotics. In the cefuroxime group, there were no cases of post-operative wound sepsis or septicaemia; in the control group, the incidence of these infections was 12.5% and 8.3% respectively.


Jul 1, 1977·The Journal of Antimicrobial Chemotherapy·R NorrbyP Hedlund
Jan 1, 1976·The Journal of Antibiotics·C H O'CallaghanP W Muggleton


Dec 1, 1984·Controlled Clinical Trials·C L MeinertK Higgins
Aug 1, 1987·Journal of Surgical Oncology·S ColizzaG Cucchiara
Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·T A Tartaglione, R E Polk

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Cephalosporanic Acids
Clinical Trials
Double-Blind Method
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