PMID: 9426995Jan 14, 1998Paper

Single dose ciprofloxacin in cholera

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
S UsubütünR Türkyilmaz

Abstract

To explore the efficacy of single dose ciprofloxacin therapy in cholera, a randomized, open, controlled clinical trial was carried out. Seventy-four adult patient with positive Vibrio cholerae 01 isolates were assigned to receive either ciprofloxacin in a single dose of 1 g (CIP1), or ciprofloxacin 500 mg b.i.d., for 1 day (CIP2), or doxycycline 100 mg b.i.d., for 3 days (D), or, for control, no antibiotics. Mean liquid stool output volume did not show any statistically significant difference among CIP1, CIP2 and doxycycline groups The mean duration of diarrhoea in CIP1 group, on the other hand, was significantly lower than that from the D group (p = 0.004), and the control group (p < 0.001). Bacteriologic clearance at the fourth day of treatment were 95.2% for CIP1, 89.5% for CIP2, 90.5% for D group and 15.4% for the control group. We conclude that a single 1 g ciprofloxacin dose is equivalent to doxycycline in its bacteriologic success but has advantages in shortening the duration of diarrhoea and simplicity of use as a single dose.

Citations

Apr 25, 2006·Journal of Clinical Gastroenterology·Doron ZamirIlia Polishchuk
Jan 16, 2004·Gut·A C Casburn-Jones, M J G Farthing
Oct 6, 2001·Gastroenterology Clinics of North America·E C Oldfield, M R Wallace
Jun 20, 2014·The Cochrane Database of Systematic Reviews·Ya'ara Leibovici-WeissmanMical Paul

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