PMID: 11906502Mar 22, 2002Paper

Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
F AuquerUrinary Tract Infection Study Group

Abstract

A double-blind, randomized controlled study to evaluate the efficacy and safety of a single dose of 500 mg of ciprofloxacin versus 3 days 400 mg twice-daily of norfloxacin in uncomplicated urinary tract infection in women was designed. Patients underwent four visits: baseline, and at 3, 7 and 28 days. The main efficacy variables were clinical and microbiological outcome at day 7. Analyses on both valid patients and intention-to-treat populations were performed. Two hundred and twenty-six patients (114 receiving ciprofloxacin and 112 receiving norfloxacin) were considered valid for efficacy evaluation. Bacteriologic cure was 91.2% in the ciprofloxacin group and 91.9% in the norfloxacin group. Clinical resolution was 91.2 and 93.8%, respectively. Both treatments were equally efficacious (P = 0.016).

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Citations

Oct 18, 2011·International Journal of Antimicrobial Agents·Kurt G NaberFlorian M E Wagenlehner
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kalpana GuptaUNKNOWN European Society for Microbiology and Infectious Diseases
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Monika Lutters, Nicole B Vogt-Ferrier
Jul 21, 2006·The Cochrane Database of Systematic Reviews·V RafalskyE Rjabkova

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