Abstract
Peak blood concentration of cyclosporine (CsA) in renal transplantation patients was recently reported to be associated with clinical efficacy. We therefore evaluated the toxicity and efficacy of a regimen of once-daily infusion of CsA plus a short course of methotrexate as prophylaxis of graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation from an HLA allele-matched, unrelated donor. Nineteen patients with hematologic malignancies received CsA, 3 mg/kg per day, as a 4-hour intravenous (IV) infusion from day -1. After engraftment, patients received CsA orally at twice the IV dose. The CsA dose was adjusted to maintain the blood trough level between 150 and 200 ng/mL. Methotrexate was administered IV at doses of 10 mg/m(2) on day 1 and 7 mg/m(2) on days 3, 6, and 11. Bone marrow engraftment occurred in all patients. Grade 1 and grade 2 GVHD occurred in 6 (31.6%) and 7 (36.8%) of the 19 patients, respectively. No patient had grade 3 or 4 GVHD. Acute nephrotoxicity developed in 1 (5.3%) of the 19 patients, and hypertension developed in 3 (15.8%) of the 19 patients. We evaluated the pharmacokinetics of 4-hour CsA infusion in 10 patients. The mean trough concentration, mean peak concentration, mean time to p...Continue Reading
References
Sep 1, 1991·British Journal of Clinical Pharmacology·T L SchwinghammerR K Shadduck
Sep 1, 1990·Transplantation·D W BeelenU W Schaefer
Apr 1, 1988·Transplantation·M S TallmanJ W Singer
Mar 20, 1986·The New England Journal of Medicine·R StorbV Farewell
Oct 1, 1974·Transplantation·H GlucksbergE D Thomas
May 27, 1995·Transplantation·T D BatiukP F Halloran
Oct 1, 1994·British Journal of Haematology·P LjungmanG Gahrton
Jan 1, 1994·Annals of Hematology·K B MillerA Rabson
Jan 1, 1994·Journal of Clinical Pharmacology·F T AweekaL Z Benet
Jun 1, 1996·British Journal of Haematology·O RingdénN C Gorin
Mar 2, 1997·Bone Marrow Transplantation·H M LazarusJ M Rowe
Oct 6, 1997·Transplantation·I W GraziadeiR A Krom
Dec 10, 1997·Transplantation·R M QuienP F Halloran
Oct 22, 1998·The New England Journal of Medicine·T SasazukiF Takaku
Nov 26, 1999·Transplantation·S G PollardR W Johnson
Nov 26, 1999·Transplantation·P F HalloranJ Noujaim
Mar 8, 2000·Transplantation·R SindhiJ Jaffe
May 9, 2000·Bone Marrow Transplantation·N ParquetE Gluckman
Oct 6, 2000·Bone Marrow Transplantation·K R SchultzP A Keown
Aug 18, 2001·Bone Marrow Transplantation·A HiraokaUNKNOWN Japanese FK506 BMT(Bone Marrow Transplantation) Study Group
May 16, 2002·Blood·Yasuo MorishimaYoshihisa Kodera
Jul 27, 2002·Therapeutic Drug Monitoring·Raymond G MorrisTimothy H Mathew
Nov 7, 2002·Bone Marrow Transplantation·M OgataM Nasu
Jan 13, 2004·Bone Marrow Transplantation·N OgawaH Hirai
Sep 17, 2004·Transplantation·Antonio TarantinoClaudio Ponticelli
Citations
Oct 5, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Olivier M NiemoellerFlorian Lang
Jun 10, 2010·International Journal of Hematology·Tatsuo FurukawaYoshifusa Aizawa
Jul 16, 2008·Bone Marrow Transplantation·M JinL L Dupuis
Aug 8, 2015·Immunotherapy·Ali Tafazoli
Apr 13, 2015·International Journal of Hematology·Makoto Murata