PMID: 8477113Apr 1, 1993Paper

Single-dose effect of enteric-coated aspirin on platelet function and thromboxane generation in middle-aged men

The Annals of Pharmacotherapy
H Mohri, T Ohkubo

Abstract

To evaluate the effect of a single dose of enteric-coated aspirin (ECA) in three different dosages on platelet function and thromboxane generation in middle-aged men. In a nonblind, nonplacebo-controlled, crossover study, a single dose of ECA (50, 250, or 1000 mg) was given in a tablet form to a group of healthy, middle-aged men. Ten subjects, aged 50-67 years, volunteered to participate in this study. Platelet functions including bleeding time, platelet aggregation, adenine nucleotides, beta-thromboglobulin, platelet factor 4, thromboxane generation, and aspirin measurement were determined. Before ECA ingestion, the intracellular adenine nucleotides (adenosine triphosphate, adenosine diphosphate) were decreased, and both beta-thromboglobulin and platelet factor 4 were increased. These observations suggested that platelets were activated in vivo in middle-aged men. These findings returned to normal within 8 hours after the ingestion of ECA, and maintained normal for at least two days. Bleeding time was significantly prolonged at 8 and 24 hours compared with that before ingestion of ECA 1000 mg (p < 0.05). The generation of platelet thromboxane was maximally inhibited by approximately 40 percent in the samples 8 hours after ECA ...Continue Reading

References

May 1, 1977·Stroke; a Journal of Cerebral Circulation·W S FieldsR J Hardy
Oct 1, 1978·American Journal of Clinical Pathology·R KumarD Deykin
Feb 1, 1978·The Journal of Clinical Investigation·J W BurchP W Majerus
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G J RothP W Majerus
Oct 31, 1991·The New England Journal of Medicine·Dutch TIA Trial Study GroupAnet van Latum
Nov 28, 1985·The New England Journal of Medicine·J A CairnsM G Myers
Aug 1, 1985·British Journal of Haematology·J A JakubowskiD Deykin
Apr 13, 1968·Lancet·J R O'Brien
Feb 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·M B Zucker, J Peterson
Aug 1, 1966·Journal of Pharmaceutical Sciences·V F Cotty, H M Ederma
Jan 12, 1980·Lancet·E M Hoogendijk, J W ten Cate
Mar 1, 1983·Clinical Pharmacology and Therapeutics·D M SiebertB W Gabb
Jan 1, 1983·Biopharmaceutics & Drug Disposition·J J ThiessenM Spino
Jan 8, 1981·The New England Journal of Medicine·F E PrestonC J Stoddard
Jun 1, 1982·The Journal of Clinical Investigation·P PatrignaniCarlo Patrono
Aug 1, 1956·The American Journal of the Medical Sciences·J J KELLY

Citations

Dec 1, 1994·Stroke; a Journal of Cerebral Circulation·C M HelgasonL D Brace
Apr 1, 1996·Stroke; a Journal of Cerebral Circulation·R G Hart, M J Harrison

Related Concepts

Zorprin
Blood Platelets
Salicylic Acids
Enteric Coated Tablet
Thromboxane B2

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.