Single-dose intraoperative antibiotic prophylaxis in emergency abdominal surgery

Archives of Surgery
B J RowlandsD G Richards

Abstract

In a randomized controlled trial of the use of a single intravenous dose of gentamicin sulfate and clindamycin phosphate used intraoperatively during emergency abdominal surgery, the overall incidence of postoperative wound infection was reduced from 32.3% to 10.4%. Significant reduction in wound infection occurred in the study group compared with control subjects irrespective of the underlying pathologic lesion. No side effects of the use of antibiotics were noted. The policy of antibiotic prophylaxis in emergency surgery seems to be of particular benefit in elderly patients.

Citations

Nov 1, 1986·American Journal of Surgery·J T DiPiroJ A Mansberger
Feb 1, 1990·American Journal of Surgery·J L SecoJ L Santamaria
Jul 22, 2005·The Cochrane Database of Systematic Reviews·B R AndersenH K Andersen
Sep 25, 2017·British Journal of Clinical Pharmacology·Rachel S HaywardJonathan D C Ross
Feb 1, 1983·Current Problems in Surgery·J T DipiroW O Griffen

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