Single-dose Intravenous Injection Toxicity of Water-soluble Danggui Pharmacopuncture (WDP) in Sprague-Dawley Rats

Journal of Pharmacopuncture
Sunju ParkSeungho Sun

Abstract

This study is to evaluate both the single-dose intravenous injection toxicity and the approximate lethal dose of Water-soluble Danggui Pharmacopuncture (WDP) in Sprague-Dawley (SD) rats. Toxicity experiments were conducted at Good Laboratory Practice (GLP) laboratory in Biotoxtech Co., according to the regulations of GLP. WDP injection of dose 0.125, 0.25, and 0.5 mL/animal were experimental groups and normal saline injection group was control group. WDP and normal saline were injected once to 6-week old 5 male and 5 female SD rats at the tail veins at approximately 2 mL/min. During 14 days after the injection, general symptoms were observed and weight were measured. After the observation period, hematological and blood biochemical examination, macroscopic autopsy, topical resistance test at the injection area were performed. RThe WDP 0.5 mL/animal injection group in 4 cases of male rats and all cases of female rats showed hematuria 30 minutes after the administration. However, after 1 hour, no more abnormal general symptoms were observed. The WDP did not affect weight, hematological and blood biochemical examination, macroscopic autopsy, and topical resistance test at the injection area. WDP single dose intravenous injection r...Continue Reading

References

Dec 17, 2002·Neurobiology of Learning and Memory·So Young KangYoung Choong Kim
Jul 25, 2003·Archives of Pharmacal Research·Sanghyun LeeSam Sik Kang
Oct 17, 2003·Archives of Pharmacal Research·Yong Yook LeeHye Sook Yun-Choi
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May 16, 2012·Anti-cancer Agents in Medicinal Chemistry·Jinhui ZhangJunxuan Lü
Mar 18, 2015·Journal of Pharmacopuncture·Min-Ji ChoiSeung-Hun Cho
Mar 18, 2015·Journal of Pharmacopuncture·Da-Jung JungTae-Han Yook
Mar 22, 2016·Journal of Pharmacopuncture·Jun-Sang YuKi-Rok Kwon
Jul 8, 2016·Journal of Pharmacopuncture·Kwang-Ho LeeSeung-Ho Sun

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