PMID: 2508501Oct 1, 1989Paper

Single dose metrifonate or praziquantel treatment in Kenyan children. I. Effects on Schistosoma haematobium, hookworm, hemoglobin levels, splenomegaly, and hepatomegaly

The American Journal of Tropical Medicine and Hygiene
L S StephensonJ Kyobe

Abstract

The relationships between S. haematobium, hookworm, malaria, hemoglobin level, splenomegaly, and hepatomegaly before and 8 months after treatment with a single dose of metrifonate or praziquantel were studied in Kenyan primary schoolchildren in an area where anemia, S. haematobium, and hookworm are common and malaria is holoendemic. Children with light to moderate S. haematobium infection were examined (Exam 1), assigned at random to groups receiving placebo (PL, n = 104), metrifonate (MT, n = 103, dose 10 mg/kg body weight) or praziquantel (PR, n = 105, dose 40 mg/kg body weight), treated, and examined 8 months later (Exam 2). At Exam 2, 62% of the MT group still passed S. haematobium eggs vs. 13% in the PR group. Egg reduction rates were substantial in both groups, but greater in the PR group; geometric mean egg counts in both groups were very low. Prevalence and intensity in the PL group had not changed between exams. Hookworm egg counts were significantly reduced in the MT group (59% egg reduction rate); malarial infection had increased in all 3 groups, presumably due to the long rainy season between exams. Hookworm egg count was the most significant predictor of initial hemoglobin level, followed by S. haematobium egg coun...Continue Reading

Citations

Apr 1, 1997·Tropical Medicine & International Health : TM & IH·J G TshikukaK N Olela
Aug 8, 2014·The Cochrane Database of Systematic Reviews·Christine V KramerPiero L Olliaro
Nov 4, 2016·The American Journal of Tropical Medicine and Hygiene·Miguel M CabadaA Clinton White
Jun 1, 1997·Nutrition Reviews·R J StoltzfusM Albonico
Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·H FriisC G Mascie-Taylor
Mar 20, 2008·Maternal & Child Nutrition·Andrew HallNilanthi de Silva

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