PMID: 2508502Oct 1, 1989Paper

Single dose metrifonate or praziquantel treatment in Kenyan children. II. Effects on growth in relation to Schistosoma haematobium and hookworm egg counts

The American Journal of Tropical Medicine and Hygiene
L S StephensonS N Kinoti

Abstract

We studied the growth of comparable groups of children with light to moderate Schistosoma haematobium infections who received a single dose of metrifonate (MT, 10 mg/kg), praziquantel (PR, 40 mg/kg), or a placebo (PL). Children were re-examined 8 months later. The MT and PR groups gained significantly more than the placebo group in weight, percent weight for age, percent weight for height, arm circumference, and in triceps and subscapular skinfold thicknesses. The MT and PR groups did not differ significantly from each other. The placebo group showed statistically significant decreases or no change between exams in percent weight for age, percent weight for height, percent arm circumference, and both skinfold thicknesses; the MT and PR groups exhibited highly significant increases in these parameters (P less than 0.0002). The intensity of S. haematobium infection had decreased significantly in both the MT and PR groups, but especially in the PR group. Multiple regression analyses showed that a decrease in the intensity of S. haematobium infection was by far the most important predictor of growth rate after treatment for all 5 anthropometric measures tested; decreases in the intensity of hookworm infection was also significant f...Continue Reading

Citations

Jan 1, 1990·Journal of Gastroenterology and Hepatology·L Mata
Mar 20, 2008·Maternal & Child Nutrition·Andrew HallNilanthi de Silva
May 14, 2020·The American Journal of Tropical Medicine and Hygiene·Charles H KingDaniel G Colley
May 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·E L CorbettR F Sturrock
Feb 1, 2002·International Journal of Epidemiology·S R MooreR L Guerrant
Jun 29, 2004·European Journal of Clinical Nutrition·A M O AssisR E Blanton
Aug 8, 2014·The Cochrane Database of Systematic Reviews·Christine V KramerPiero L Olliaro
Nov 30, 2012·Parasites & Vectors·Humphrey D MazigoDavid W Dunne
Aug 23, 2005·Memórias do Instituto Oswaldo Cruz·Iran Mendonça da SilvaPaulo César Ribeiro
May 30, 2009·PLoS Neglected Tropical Diseases·A Desiree LabeaudCharles H King
Sep 15, 2000·Infectious Disease Clinics of North America·I BicaM J Stadecker
Jun 24, 1994·Science·D B Evans, D T Jamison

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