Single dose of anti-D immune globulin at 75 microg/kg is as effective as intravenous immune globulin at rapidly raising the platelet count in newly diagnosed immune thrombocytopenic purpura in children

The Journal of Pediatrics
Michael TarantinoAcute ITP Study Group

Abstract

To conduct a randomized prospective trial of immune globulin treatment for 105 Rh+ children with newly-diagnosed immune thrombocytopenic purpura and a platelet count<20,000/microL, to determine whether anti-D immune globulin (anti-D) is as effective as intravenous immune globulin (IVIg). Eligible patients received either a single intravenous dose of 50 microg/kg anti-D (anti-D50), 75 microg/kg anti-D, (anti-D75), or 0.8 g/kg IVIg, (IVIg). Patients were monitored for response to treatment and adverse events. By 24 hours after treatment 50%, 72%, and 77% of patients in the anti-D50, anti-D75, and IVIg groups, respectively, had achieved a platelet count>20,000/microL (P=.03). By day 7, hemoglobin concentrations decreased by 1.6 g/dL, 2 g/dL, and 0.3 g/dL in the anti-D50, anti-D75, and IVIg groups, respectively. Headache, fever, or chills occurred least often in the anti-D50 group. A single 75 microg/kg dose of Anti-D raised the platelet count in children with newly diagnosed immune thrombocytopenic purpura more rapidly than standard-dose anti-D and as effectively as IVIg, with an acceptable safety profile.

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Citations

Jul 11, 2009·Clinical Reviews in Allergy & Immunology·Shaye KivityYehuda Shoenfeld
Aug 22, 2008·Indian Journal of Pediatrics·V GuptaB D Bhatia
Dec 19, 2009·Indian Pediatrics·Rahul NaithaniPravas Mishra
Apr 15, 2010·Journal of Tropical Pediatrics·Dinesh YadavVarinder Singh
Dec 10, 2013·Hematology·Jenny M Despotovic, Cindy E Neunert
Aug 14, 2008·Blood·Cindy E NeunertUNKNOWN Intercontinental Childhood ITP Study Group Registry II Participants
Jan 7, 2014·European Journal of Pediatrics·Veerle Labarque, Chris Van Geet
Oct 30, 2007·La Revue de médecine interne·B Godeau
Feb 18, 2011·Blood·Cindy NeunertUNKNOWN American Society of Hematology
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Sep 17, 2013·Pediatric Blood & Cancer·Michael D DeelSalvatore J Bertolone
Oct 16, 2007·Current Opinion in Hematology·Biree Andemariam, James Bussel
Oct 16, 2007·Current Opinion in Hematology·Michael D Tarantino, Paula Hb Bolton-Maggs
Sep 2, 2009·Pediatric Blood & Cancer·Mimi KjaersgaardHenrik Hasle
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Aug 23, 2019·Science Translational Medicine·Andrew R CrowAlan H Lazarus
Jan 16, 2018·Blood Research·Jun Ho JangUNKNOWN on the behalf of Korean Aplastic Anemia Working Party
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Mar 12, 2020·The New England Journal of Medicine·Nichola Cooper, Waleed Ghanima
Mar 20, 2021·Blood Reviews·Manpreet Kochhar, Cindy Neunert

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