Single dose of cefodizime completely eradicated multidrug-resistant strain of Neisseria gonorrhoeae in urethritis and uterine cervicitis

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Tetsuro MatsumotoShigeaki Yanai

Abstract

Cefodizime (CDZM) has strong antimicrobial activity to Neisseria gonorrhoeae in vitro. However, multidrug-resistant N. gonorrhoea emerged and has been increasing in Japan. To know the effectiveness of CDZM on gonococcal urethritis and uterine cervicitis even in the era of multidrug-resistant N. gonorrhoeae, a clinical trial of single-dose therapy of CDZM for gonococcal urethritis and uterine cervicitis was conducted. N. gonorrhoeae was eradicated from 100% of patients with gonococcal urethritis and uterine cervicitis by a single dose of CDZM. In conclusion, CDZM is one of most suitable drugs for the treatment of gonococcal genital infection in the era of multidrug-resistant N. gonorrhoeae.

References

Dec 1, 1981·Antimicrobial Agents and Chemotherapy·R N JonesH W Wilson
Nov 16, 2001·Antimicrobial Agents and Chemotherapy·T MurataniT Matsumoto
Feb 7, 2002·Expert Opinion on Pharmacotherapy·John Tapsall
Sep 15, 2004·International Journal of Antimicrobial Agents·Masatoshi TanakaIntetsu Kobayashi

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Citations

Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lori M NewmanKimberly A Workowski
Jul 17, 2012·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Satoshi TakahashiTaiji Tsukamoto
Jul 21, 2010·The Journal of Urology·Takashi DeguchiShin-ichi Maeda
Jun 10, 2008·International Journal of Antimicrobial Agents·Munekado KojimaTetsuro Matsumoto
Jul 31, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Tetsuro MurataniTetsuro Matsumoto
Jan 1, 2008·International Journal of Antimicrobial Agents·T Matsumoto
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Pennan M Barry, Jeffrey D Klausner

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