PMID: 6401550Feb 5, 1983Paper

Single dose oral treatment in urinary schistosomiasis: a double blind trial

British Medical Journal
R N Pugh, C H Teesdale

Abstract

A double blind trial of three oral preparations given in single doses for the treatment of Schistosoma haematobium infection was carried out in schoolchildren; selection was biased towards those who excreted large quantities of eggs. Praziquantel 40 mg/kg was the most effective drug giving a greater than 97% reduction in egg output six months after treatment; combined treatment with niridazole 25 mg/kg and metrifonate 10 mg/kg gave a reduction of greater than 92% and metrifonate 10 mg/kg alone a reduction of greater than 86%. Fewer children continued to have moderate to heavy infections (excretion greater than 124 ova/10 ml urine) six months after treatment with praziquantel (5%) and the combined regimen (7%) than with metrifonate (16%). Though our findings show that praziquantel appears to be the most effective and convenient drug available for individuals with S haematobium infection, the combined regimen is a cheaper alternative for treatment where cost is important and parasitological cure not an essential objective.

References

Sep 1, 1977·The American Journal of Tropical Medicine and Hygiene·P Jordan
Aug 1, 1978·Annals of Tropical Medicine and Parasitology·R N Pugh
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·H FeldmeierA A Daffalla
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·J E McMahon

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Citations

Jan 1, 1989·European Journal of Clinical Pharmacology·Y Aden Abdi, L L Gustafsson
Jan 1, 1987·European Journal of Clinical Pharmacology·Y Aden-AbdiS A Elmi
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·R N Pugh, C H Teesdale
Sep 24, 1983·British Medical Journal·R N Pugh, C H Teesdale
Nov 20, 1993·BMJ : British Medical Journal·R N Pugh
Aug 23, 2005·Memórias do Instituto Oswaldo Cruz·Iran Mendonça da SilvaPaulo César Ribeiro
Aug 8, 2014·The Cochrane Database of Systematic Reviews·Christine V KramerPiero L Olliaro
Jul 1, 1985·Medicinal Research Reviews·V K Agrawal, S Sharma
Nov 20, 1993·BMJ : British Medical Journal·J L Sullivan
Nov 20, 1993·BMJ : British Medical Journal·E C Ashby
Jul 25, 2013·Expert Review of Anti-infective Therapy·J Russell StothardAnnalan M D Navaratnam

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