PMID: 60565Aug 14, 1976Paper

Single-dose peroperative antibiotic prophylaxis in gastrointestinal surgery

D A GriffithsN B Williams


A single intravenous dose of tobramycin and lincomycin, given at the start of gastrointestinal operations, significantly reduced the incidence of postoperative wound infection from 34% to 5%. The occurrence of both anaerobic and aerobic bacteria was reduced. Therapeutic concentrations of the antibiotics were maintained throughout the operative period in most cases. No toxic effects of the antibiotics were detected, no anaesthetic complication occurred, and resistant strains of bacteria normally sensitive to the antibiotics were not isolated from wounds.


Aug 1, 1976·The Journal of Infectious Diseases·A P GillettV Melikian


May 1, 1982·World Journal of Surgery·T J Muscroft, S A Deane
May 1, 1983·Diseases of the Colon and Rectum·J PortnoyJ Mendelson
Mar 1, 1980·Diseases of the Colon and Rectum·K C HanelE Reiss-Levy
Dec 14, 1978·The New England Journal of Medicine·N L TilneyJ P Merrill
Apr 1, 1980·Annals of Surgery·E P DellingerM Steer
Jun 1, 1978·Anaesthesia·T A Boliston, R Ashman
Aug 12, 1978·British Medical Journal·C MorranC S McArdle
Jun 14, 1980·British Medical Journal·R B Galland
May 1, 1980·Postgraduate Medical Journal·A K Islam, J M Shneerson
Nov 1, 1979·American Journal of Surgery·R T LewisF M Wiegand
Aug 1, 1987·The British Journal of Surgery·S Paterson-BrownH A Dudley
Apr 1, 1995·The British Journal of Surgery·J M BadiaA Sitges-Serra
Feb 1, 1980·The British Journal of Surgery·A F HigginsM L Hole
May 1, 1977·The British Journal of Surgery·M R Keighley
Aug 1, 1980·British Journal of Urology·M WilliamsT B Hargreave
Jul 22, 2005·The Cochrane Database of Systematic Reviews·B R AndersenH K Andersen
Mar 2, 2006·The Journal of Antimicrobial Chemotherapy·Curtis G GemmellJoint Working Party of the British Society for Joint Working Party of the British Society for Antimicrobial Chemotherapy, Ho
Nov 9, 2012·The Journal of Trauma and Acute Care Surgery·Stephanie R GoldbergEastern Association for the Surgery of Trauma
May 1, 1982·Infection Control : IC·M C NahataD A Powell

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