PMID: 9549666Apr 29, 1998Paper

Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers

Journal of Clinical Pharmacology
Y N WongP E Grebow

Abstract

Modafinil is a novel wake-promoting agent being developed for treatment of excessive daytime sleepiness associated with narcolepsy. An open, 3 x 3 Latin square, randomized, cross-over study was performed in healthy males to compare the pharmacokinetics of single-dose oral modafinil (200 mg) and methylphenidate (40 mg) administered alone or in combination. Blood samples were obtained for analysis of d- and l-threo-methylphenidate and modafinil and its acid and sulfone metabolites. Pharmacokinetic parameters were determined by noncompartmental methods, but could not be evaluated for modafinil sulfone due to plasma levels that were close to the assay quantitation limit. Although sporadic differences in plasma concentrations were observed between treatments, coadministration of modafinil and methylphenidate did not significantly alter the plasma concentrations of modafinil, modafinil acid, modafinil sulfone, or methylphenidate enantiomers compared with administration of these agents alone. Half-life (t1/2), maximum concentration (Cmax), area under the concentration-time curve (AUC0-infinity), total clearance (Cl/F), and apparent volume of distribution (Vd/F) for modafinil and t1/2, Cmax, and AUC0-infinity for modafinil acid were no...Continue Reading

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Citations

Jun 3, 2008·Psychopharmacology·Andrew D BlackwellBarbara J Sahakian
Mar 31, 2010·Psychopharmacology·Kathrin FinkeUlrich Müller
Apr 12, 2003·Drug and Alcohol Dependence·Charles A DackisCharles P O'Brien
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