Single-dose pharmacokinetics of recombinant human erythropoietin in patients with various degrees of renal failure

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
J KindlerH G Sieberth

Abstract

The pharmacokinetic profile of recombinant human erythropoietin (rHuEpo) was studied after a single intravenous dose of 150 U/kg in ten patients with various degrees of renal function: group I, creatinine clearance greater than 80 ml/min, n = 2; group II, creatinine clearance 10-50 ml/min, n = 6; group III, creatinine clearance less than 3 ml/min (patients undergoing haemodialysis) n = 2. Erythropoietin concentrations in serum and urine samples obtained over 48 h were measured by RIA. rHuEpo was cleared from circulation in an exponential fashion, the half-life ranged from 6.5 to 12.7 h (mean 9.03 h) and was not different between the groups. The apparent volume of distribution varied from 0.041 to 0.099 l/kg (mean 0.070 l/kg) this corresponds to 1.5 times the plasma volume and was unrelated to kidney function. Renal clearance (groups I, II) accounted for less than 3% of total body clearance, both parameters were unaffected by decreasing renal function. These results indicate that, in accordance with animal data, the elimination of rHuEpo occurs mainly through non-renal mechanisms.

Citations

Dec 3, 1999·European Journal of Clinical Investigation·S M FreudenthalerC H Gleiter
Jun 10, 2015·Nature Reviews. Nephrology·Mark J Koury, Volker H Haase
Dec 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·J D JensenE B Pedersen
Jan 1, 1993·Vox Sanguinis·S J Schuster, J Caro
Jul 1, 1993·Postgraduate Medical Journal·K Farrington, P Sweny
Sep 1, 1993·Journal of Cardiac Surgery·R E HelmK H Krieger
Oct 10, 2007·Expert Opinion on Investigational Drugs·Francesco Locatelli, Bruno Reigner
May 9, 1991·The New England Journal of Medicine·A J Erslev
Dec 1, 2005·Pediatric Blood & Cancer·Burgess B FreemanClinton F Stewart
Apr 13, 2007·Clinical Pharmacology and Therapeutics·J A WidnessP Veng-Pedersen
Jan 18, 2012·Journal of Clinical Pharmacology·Bernd Meibohm, Honghui Zhou
Jan 17, 2012·British Journal of Clinical Pharmacology·David CzockHanna M Seidling
Feb 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A BraunK Schärer
Feb 1, 1994·The American Journal of Medicine·M E Eberst, L R Berkowitz
Aug 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E P PaganiniD A Goodkin
Aug 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N MuirheadP Parfrey
Mar 1, 1995·Kidney International·R G CarliniM Rothstein

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